Adding a certain compound to certain chemical reactions, such as: 17826-05-0, name is 5,6-Dibromoindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17826-05-0, Formula: C8H3Br2NO2
To a solution of 1 (0.327) in THF (10 ml) a solution of 1 M BH3¡¤THF (2.5 equiv) was added dropwise at 0 C, then the mixture was stirred at rt for 3 h. After this time, the reaction was quenched by slowly adding 2 ml of demineralized water, then 2N HCl was added to pH 3. THF was removed under reduced pressure and the aqueous residue extracted with two portions of EtOAc. The organic layers were washed with two portions of brine, dried over Na2SO4 and evaporated under reduced pressure to give a yellow oil. The crude product was purified by silica gel chromatography (petroleum benzene/Et2O 9:1) to give the pure product 2 as a greyish crystalline solid, mp = 154-155 C, Rf = 0.2 (Et2O/petroleum ether 1:5), 68%. 1H NMR, 300 MHz, DMSO-d6 delta = 6.42 (1H, m, H3), 7.42 (1H, t, H2), 7.75 (1H, s, H7), 7.93 (1H, s, H4), 11.35 (1H, brs, NH). 13C NMR, 75 MHz, DMSO-d6 delta = 101.53, 113.62, 115.45, 116.71, 124.96, 128.76, 129.44, 136.35.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dibromoindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mollica, Adriano; Stefanucci, Azzurra; Feliciani, Federica; Lucente, Gino; Pinnen, Francesco; Tetrahedron Letters; vol. 52; 20; (2011); p. 2583 – 2585;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem