Author: Jessica.F

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 550-44-7, Name is 2-Methylisoindoline-1,3-dione, molecular formula is , belongs to indolines-derivatives compound. In a document, author is Hajra, Saumen, Product Details of 550-44-7.

Catalyst-Free Stereocontrolled Formal [3+2]-Cycloaddition of CO2 for the Synthesis of Enantiopure Spiro[indoline-3,5 ‘-oxazolidine]-2,2 ‘-diones under Aqueous and Ambient Conditions

A highly efficient regio- and stereoselective spontaneous formal [3 + 2]-cycloaddition of CO2 in aqueous medium is developed for the one-pot synthesis of spiro[indoline-3,5′-oxazolidine]-2,2’-diones with excellent enantiopuirity (ee up to 99%) under catalyst-free and ambient conditions. The detailed study reveals NH-spiroaziridine- and 3-(aminomethyl)-3-chloro-oxindoles, two in situ generated reactive intermediate compounds for the spontaneous cycloaddition with CO2, and the latter is responsible for the stereoselectivity. An unprecedented mechanism of desulfinylation is also disclosed herewith.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 550-44-7, in my other articles. Product Details of 550-44-7.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@H]2CN(C3=CC=C(N4C(COCC4)=O)C=C3)C(O2)=O)C(C5=C1C=CC=C5)=O, in an article , author is Chen, Jinzhou, once mentioned of 446292-08-6, Safety of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

Blue Light-Promoted Formal [4+1]-Annulation of Diazoacetates with o-Aminoacetophenones: Synthesis of Polysubstituted Indolines and Computational Study

A blue light-promoted formal [4+1]-annulation of diazoacetates with o-aminoacetophenones has been reported, which provides an environmentally friendly method for the synthesis of polysubstituted indoline derivatives in moderate to good yields with excellent diastereoselectivities. Detailed mechanistic studies through density functional theory calculations reveal that the (E)-enol species is the key intermediate in this transformation, and the excellent diastereoselectivity is enabled via H-bonding in the intramolecular Aldol-type addition.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 446292-08-6, you can contact me at any time and look forward to more communication. Safety of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.

In an article, author is de Carvalho, Matheus Antoniel Felix, once mentioned the application of 550-44-7, Quality Control of 2-Methylisoindoline-1,3-dione, Name is 2-Methylisoindoline-1,3-dione, molecular formula is C9H7NO2, molecular weight is 161.16, MDL number is MFCD00023063, category is indolines-derivatives. Now introduce a scientific discovery about this category.

A potential material for removal of nitrogen compounds in petroleum and petrochemical derivates

Activated carbon from coconut shell (Elaeis guineensis), in both crude and chemically modified forms, was evaluated as an adsorbent for removing nitrogen compounds of samples from synthetic and real fuel. The preliminary adsorption tests showed that 97.95 of indoline was removed by sulfuric acid-treated activated carbon (SAAC). The optimum conditions toward adsorption of nitrogen-containing compounds in crude oil (54 degrees C, 150 rpm and 1.104 g of adsorbent) was evaluated according to the design of experiments (DOE) technique associated with Differential Evolution optimization algorithm and an effective removal of 30.37% of basic nitrogenous compounds present in crude oil was achieved. For comparative effect, the tests were carried out using the previously optimized condition with the vacuum residue, diesel S-500, and diesel S-10, obtaining the removal of 21.56%, 44.44%, and 62.09%, respectively. Complementing the quantitative analysis, the analysis of mass spectrometry confirmed that coconut shell is a potential material for selective adsorption of nitrogenous compounds.

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, formurla is C11H9NO3. In a document, author is Cheng, Dao-Juan, introducing its new discovery. Recommanded Product: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Diastereoselective Synthesis of Functionalized Indoline N,O-Aminals: Unexpected Water-Involved Cascade Reaction of 3H-Indoles and Oxazol-5-(4H)ones

Herein, we describe an unexpected TsOH center dot H2O-mediated domino three-component reaction of 3H-indoles, oxazol-5-(4H)ones, and water, allowing rapid access to a new family of structurally unique indoline N,O-aminals bearing a valuable alpha-acylaminoamide moiety in high yields and excellent diastereoselectivities. The scaled-up experiment and various transformations of the products further demonstrate the utility of this chemistry. Moreover, a preliminary study on the catalytic asymmetric version of this novel 1,2-difunctionalization reaction is performed.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 161596-47-0 help many people in the next few years. Recommanded Product: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.

Reference of 550-44-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 550-44-7, Name is 2-Methylisoindoline-1,3-dione, SMILES is CN1C(=O)C2=C(C=CC=C2)C1=O, belongs to indolines-derivatives compound. In a article, author is Liang, Guoduan, introduce new discover of the category.

Diastereoselective Syntheses of Spiro[indoline-3,4 ‘-pyridin]-2-yl Carbamates via AgOTf/Ph3P-Catalyzed Tandem Cyclizations of Tryptamine-Ynesulfonamides

Spiro[indoline-3,4′-piperidine] is a significant structural scaffold in numerous polycyclic indole alkaloids with a variety of bioactivities. In this study, a synthetic strategy was developed to access spiro[indoline-3,4′-pyridin]-2-yl carbamate via an AgOTf/ PPh3-catalyzed tandem cyclization of tryptamine-ynesulfonamides. The unique feature of this strategy is the efficient intermolecular capturing of the in situ generated spiroindoleninium intermediates with carbamates, leading to the diastereoselective syntheses of spiro[indoline-3,4’-pyridin]-2-yl carbamate derivatives. A broad scope of this cyclization was demonstrated by a variety of tryptamine-ynesulfonamide substrates and several carbamates. A plausible mechanism of this reaction was proposed.

Reference of 550-44-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 550-44-7 is helpful to your research.

Reference of 161596-47-0, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Nakamura, Takumi, introduce new discover of the category.

Chiral bifunctional sulfide-catalyzed asymmetric bromoaminocyclizations

A BINOL-derived chiral bifunctional sulfide catalyst bearing a phenylurea moiety was applied to enantioselective bromoaminocyclization reactions of 2-allylaniline derivatives, which provide optically active 2-substituted indoline products as important motifs for biologically active compounds. A protecting group on the nitrogen of the 2-allylaniline substrate was carefully optimized, and highly enantioselective reactions were achieved by employing the p-biphenylsulfonyl-protected substrates. The origin of the good level of enantioselectivity for the present bromoaminocyclization was also investigated on the basis of DFT calculations. The resultant optically active 2-(bromomethyl)indoline products could be transformed to various 2-substituted indolines with no loss of the optical purity.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 59-48-3, Name is Indolin-2-one, molecular formula is C8H7NO. In an article, author is Wen, Jiang-Bo,once mentioned of 59-48-3, Recommanded Product: Indolin-2-one.

Squaramide-catalysed asymmetric cascade reactions of 2,3-dioxopyrrolidines with 3-chlorooxindoles

A highly efficient method for the enantioselective construction of dispirocyclic compounds has been developed by the squaramide-catalysed asymmetric Michael addition/cyclization cascade reaction of 2,3-dioxopyrrolidines with 3-chlorooxindoles. The corresponding chiral dispiro[indoline-3,1 ‘-cyclopropane-2 ‘,3 ”-pyrrolidine]-2,4 ”,5 ”-triones were obtained in high yields with excellent stereoselectivities (up to 94% yield, >25 : 1 dr and >99% ee). Furthermore, a gram-scale experiment confirmed the reliability of the current reaction and further effective transformation of the product has been realized.

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Reference of 99365-40-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99365-40-9, Name is 6-Bromoindolin-2-one, SMILES is O=C1NC2=C(C=CC(Br)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Zhang, Weiyi, introduce new discover of the category.

Computational Protocol for Precise Prediction of Dye-Sensitized Solar Cell Performance

Numerous organic dyes have been developed for dye-sensitized solar cells (DSSCs). However, theoretical screening has not played a due role in designing new dyes. It is mainly attributed that there is rarely quantitative calculation and the inaccurate estimated values for short-circuit current density (J(SC)) and open-circuit photovoltage (V-OC), especially for V-OC. In this work, V-OC is theoretically predicted by two different models for three D-pi-A organic dyes (1, 2, and 3) with the same pi bridge and acceptor as well as different donors. Although there is a slight deviation in their structures, their properties are successfully differentiated by accurate quantitative calculations. Dimethoxybenzene-substituted indoline is more suitable as donor than methoxy-substituted triphenylamine and methyl-substituted indoline when it combines with 8H-thieno [2′,3′:4,5]thieno [3,2-b]thieno [2,3-d]pyrrole (TTP) as pi bridge and cyanoacrylic acid as acceptor. The properties of the donor are not only related to the core group but are also determined by the substituted group. A less than 10% deviation between theoretical and experimental results is an assurance to perform a reasonable prediction for photocurrent-photovoltage.

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Palanivel, Suresh, once mentioned the application of 88150-75-8, Name is Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate, molecular formula is C16H17NO6, molecular weight is 319.31, MDL number is MFCD12407176, category is indolines-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate.

Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4 ‘-methylphenyl) methyl) indoline in breast cancer cells

Indoline derivatives functions as an inhibitors of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers. We aim to investigate anti-breast cancer effects and mechanism of action of novel indoline derivatives. Molecular docking of seven indoline derivates with EGFR revealed, N-(2-hydroxy-5-nitrophenyl (4’-methylphenyl) methyl) indoline (HNPMI) as the top lead compound. RT-PCR analysis showed the downregulation of PI3K/S6K1 genes in breast cancer cells through the activation of EGFR with HNPMI. This compound found to have higher cytotoxicity than Cyclophosphamide, with the IC50 of 64.10 mu M in MCF-7 and 119.99 mu M in SkBr3 cells. HNPMI significantly reduced the cell proliferation of MCF-7 and SkBr3 cells, without affecting non-cancerous cells, H9C2. Induction of apoptosis was analyzed by Caspase-3 and -9, DNA fragmentation, AO/EtBr staining and flow cytometry assays. A fold change of 0.218- and 0.098- for caspase-3 and 0.478- and 0.269- for caspase-9 in MCF7 and SkBr3 cells was observed, respectively. Caspase mediated apoptosis caused DNA fragmentation in breast cancer cells upon HNPMI treatment. The structural elucidation of HNPMI by QSAR model and ADME-Tox suggests, a bi-molecular interaction of HNPMI-EGFR which is related to antiproliferative and apoptotic activity. The data concludes that, HNPMI-induced the apoptosis via EGFR signaling pathway in breast cancer cells. Thus, HNPMI might serve as a scaffold for developing a potential anti-breast cancer therapeutic agent.

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Electric Literature of 88150-75-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 88150-75-8, Name is Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate, SMILES is O=C(OCC)CC(COCCN(C(C1=C2C=CC=C1)=O)C2=O)=O, belongs to indolines-derivatives compound. In a article, author is Alfano, Antonella Ilenia, introduce new discover of the category.

Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds

A greener and sustainable flow chemistry protocol for the synthesis of 3,3-disubstituted indolenines through interrupted Fischer indolisation reaction is described. First, two model aldehydes were reacted with phenylhydrazine in order to explore the reaction feasibility in a ‘greener’ fashion in batch mode. The best outcomes were then used as the starting point for the implementation of the reaction in continuous flow. A thorough exploration of key parameters allowed the identification of the most efficient reagent mixing mode, and the optimum temperature and residence time. The newly developed method allowed straightforward reaction channelling towards the formation of the indolenines, thus reducing the competitive formation of side products. We further broadened the scope of the conceived methodology by exploring the possibility of a heterogeneous in-line reduction of the indolenines to their indoline counterparts. This rapid approach nicely complements known batch chemistry and could facilitate synthesis and scale up of 3,3-disubstituted indolenines and indolines, offering a coupling point for additional and subsequent flow reactions for multistep syntheses for further derivatization.

Electric Literature of 88150-75-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 88150-75-8 is helpful to your research.