Author: Jessica.F

Reference of 317-20-4,Some common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, molecular formula is C8H4FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(E) -N-Benzyl-2-nitro-N- (p-tolyl) ethane- 1,1-diamine (1 milliliter(1 mmol)) and 7-fluoroindoline-2,3-dione (1 mmol) were added, toluene (15 ml) and trifluoroacetic acidUnder stirring, the mixture was heated to 110 C and refluxed for 14 hours. TLC monitoring reaction until the point of complete disappearance of raw materials, the reaction solutionExtraction was performed by adding 50 ml of ethyl acetate and 50 ml of saturated sodium chloride aqueous solution, the organic layer was dried over anhydrous Na2SO4,The dried organic phase was concentrated to dryness under reduced pressure, and then 3 ml of acetone and 4 g of 100-200 mesh siliconStir the plastic, vacuum evaporated to dryness, the sample was separated with a petroleum ether / ethyl acetate = 7: 1 eluent silica gel column dried to obtain redN-Benzyl-8-fluoro-3-nitro-2- (p-tolylamino) quinoline-4-carboxamide (Compound 40) was obtained in 65% yield.

The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yunnan University; Yan Shengjiao; Wang Baoqu; Lin Jun; (25 pag.)CN107522659; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 239463-85-5, name is (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, A new synthetic method of this compound is introduced below., Computed Properties of C26H31N3O8

Step S301: In a 500 mL three-necked bottle, respectively add 5.14 g of 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro -7-cyano-1H-indole tartrate, 150mL dichloromethane, 5mL triethylamine, and stir;After stirring and dissolving, 2.18 g of di-tert-butyl dicarbonate was added in portions, and the reaction was stirred at room temperature for 2 h to obtain a reaction solution;Add 100 mL of purified water to the above reaction solution, stir for 10 min, then stand still for layering;Wash the separated organic phase with 100 mL of purified water and 100 mL of saturated sodium chloride, and then dry the organic phase with anhydrous sodium sulfate for 2 h, and then filter to obtain a filtrate;The filtrate was concentrated under reduced pressure to obtain 3.92 g of light yellow oily compound II, which was 5-[(2R)-2-(tert-butoxycarbonyl)aminopropyl]-1-[3-(benzoyloxy ) Propyl]-2,3-dihydro-7-cyano-1H-indole, the yield of which is 84.48%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Beijing Xinkaiyuan Pharmaceutical Technology Co., Ltd.; Chai Guoju; Zhang Ding; Wu Yanpeng; Li Jing; Ge Zhimin; Dai Xinmin; (17 pag.)CN111116448; (2020); A;,
Indoline – Wikipedia,
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Some common heterocyclic compound, 20870-78-4, name is 5-Bromoindolin-2-one, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 20870-78-4

5-Phenyloxindole 5-Bromo-2-oxindole (5 g, 23.5 mmol) was dissolved in 110 mL toluene and 110 mL ethanol with stirring and a little heat. Tetrakis(triphenylphosphine)palladium(0) (1.9 g, 1.6 mmol) was added followed by 40 mL (80 mmol) 2M aqueous sodium carbonate. To this mixture was added benzene boronic acid (3.7 g, 30.6 mmol) and the mixture was heated in a 100 C. oil bath for 12 hours. The reaction was cooled, diluted with ethyl acetate (500 mL), washed with saturated sodium bicarbonate (200 mL), water (200 mL), 1N HCl (200 mL) and brine (200 mL). The organic layer was dried over magnesium sulfate and concentrated to afford a brown solid. Trituration with dichloromethane afforded 3.8 g (77%) of 5-phenyl-2-oxindole as a tan solid. 1H NMR (360 MHz, DMSO-d6) delta 10.4 (br s, 1H, NH), 7.57 (dd, J=1.8 and 7.2 Hz, 1H), 7.5 to 7.35 (m, 5H), 7.29 (m, 1H), 6.89 (d, J=8.2 Hz, 1H), 3.51 (s, 2H, CH2CO). MS m/z 209 [M+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20870-78-4, its application will become more common.

Reference:
Patent; Sugen, Inc.; US6878733; (2005); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3335-98-6 as follows. Recommanded Product: 3335-98-6

General procedure: A mixture of isatins (1, 1.0 mmol), indolin-2-ones (2, 1.0 mmol) and ZrCl4 (23 mg, 0.1 mmol) was heated in anhydrous ethanol (5 mL) under reflux. After the disappearance of the reactants (8-12 h, monitored by TLC), the mixture was slowly cooled to room temperature. The red solids precipitated and were collected by filtration, then washed by a small amount of anhydrous ethanol to deliver pure compounds 3.

According to the analysis of related databases, 3335-98-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Meilin; Qiu, Shaozhong; Ye, Yu; Yin, Guodong; Tetrahedron Letters; vol. 57; 52; (2016); p. 5856 – 5858;,
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Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 324-03-8, name is 6-Fluoroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Fluoroindoline-2,3-dione

Exampie 1; 7-fluoro-3-hvdroxvquinolin-2{1H)-one; The title compound was prepared by the procedure depicted Sn Scheme 1 and described in detail below, using the general method of S-Y. Sit et al., Bioorqanic Medicinal Chem Lett.1996, beta, 499. Step 1. 6-Fluoro-1H-indo.e-2,3-dione (6-fluoroisatin, 200 mg, 1.2 mMoi), diethylamide (0.24 ml. 2.3 mMol), and ethyl diazoacetate (0,24 mL 2.3 mMol) were dissolved in ethanoi (15 mL) and stirred at room temperature for 64 hours. Removal of solvent in vacuo then provided the diazo intermediate as an Oil (LCMS m/z 278.0 [M-1]); this was treated with hydrochloric acid (1N, 75 rnL), and allowed to react for 40 hours at room temperature Filtration of the reaction mixture yielded ethyl 7-f.uoro-3- hydroxy-2-oxo-1.2-dihyo’roquinoiine-4-carboxylate as an orange solid (144 mg, 0.57 mMol). LCMS m/z 252.1 (M+1). 1H NMR (400 MHz, CD3OD) delta 1.42 (t, J^7,0 Hz13H), 4.48 (q, J =7.0 Hz, 2H)8 7.02 (m, 2H), 7.87 (del. J =5.6. 8.9 Hz, 1H).

The synthetic route of 324-03-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; DUPLANTIER, Allen Jacob; GAN, Xinmin; HU, Lain-Yen; LU, Jiemin; SHEEHAN, Susan Mary Kult; WO2010/58314; (2010); A1;,
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Reference of 132898-96-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 132898-96-5 name is 2,3-Dioxoindoline-5-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of dimethylamine (2M solution in THF) (0.668 mmol, 1.3 eq) and DIPEA (0.139 g, 1.02 mmol, 2 eq) was added to a solution of rpm 121 (0.126 g, 0.514 mmol) in anhydrous THF (4 ml) at 0 0C under Ar. The reaction mixture was stirred overnight at room temperature, and the mixture was poured into water (5 ml). The product was extracted with ethyl acetate (3 x 10 ml). The organic extracts were collected, dried over Na2SO4 and the solvent removed under reduced pressure. The pure compound rpm 123 was obtained after trituration with ethyl acetate (5 ml) as a yellow solid (0.90 g, 0.354 mmol, 68%), mp 150- 152 0C (lit mp 233 0C.) 1H NMR (400 MHz, DMSO-d6) delta 2.60 (6H, s), 7.09 (IH, d, J 8.3 Hz), 7.68 (IH, d, J2.0 Hz), 7.91 (IH, dd, J 8.3, 2.0 Hz), 1 1.44 (IH, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dioxoindoline-5-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF SOUTH FLORIDA; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; WO2007/117699; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 56341-37-8, name is 6-Chlorooxindole, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56341-37-8, COA of Formula: C8H6ClNO

6-Chloroindolin-2-one (8.35 g, 50 mmol) and 3-chloro-2-fluorobenzaldehyde (8.295 g, 52.5 mmol) were stirred at reflux in the presence of piperidine (1 ml) for 6 hours. The reaction suspension was then filtered, and the solid obtained was washed with methanol and dried to give a yellow solid product, (E)-6-chloro-3-(3-chloro-2-fluorobenzylidene)indol2-one (14.63g, 47.5mmol). Yield: 95%. 1H NMR (400MHz, DMSO): delta 10.85 (s, 1 H), 7.70 (q, J=7.3Hz 2 H), 7.54 (s, 1 H), 7.36 (t, J=8Hz 1 H), 7.16 (d, J=8Hz 1 H), 6.92-6.86 (m, 2 H); MS: Calcd for C15H9Cl2FNO ([M+H]+): 308, found: 308.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Xiao, Fei; MA, Jie; XIAO, Fei; REN, Hongjun; WANG, Wei; XU, Hongtao; WANG, Meng; ZOU, Lihui; DING, Fei; SU, Fei; (41 pag.)EP3498712; (2019); A1;,
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Electric Literature of 5332-26-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5332-26-3 name is 2-(Bromomethyl)isoindoline-1,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The vacuum dried intermediate 3 (0.002 mol) was then reacted with mono- and di-substituted benzoic acids (0.003 mol) separately in presence of anhydrous potassium carbonate (0.003 mol) in DMF (10 mL). The reaction mixture was stirred at room temperature for about 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water and allowed stir for 10 min. The solid obtained was filtered and washed successively with distilled water and recrystallized from ethanol to obtain4(a-n).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Bromomethyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Reference:
Article; Kumar, C.S. Chidan; Loh, Wan-Sin; Chandraju, Siddegowda; Win, Yip-Foo; Tan, Weng Kang; Quah, Ching Kheng; Fun, Hoong-Kun; PLoS ONE; vol. 10; 3; (2015);,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 132898-96-5 as follows. Application In Synthesis of 2,3-Dioxoindoline-5-sulfonyl chloride

General procedure: To a stirred solution of the N-Boc-protected pyrrolidine (1.0 mmol) in dry DCM (3 mL) at 0 C under argon atmosphere, TFA (1.14 g, 10.0 mmol) was added dropwise. The obtained solution was stirred at 0 C for 30 min followed by stirring at r.t. for 2 h. Subsequently, the solution was poured to cold 10% aq. NaOH (15 mL) and extracted with DCM (3 ¡Á 15 mL). The combined organic phases were dried over MgSO4 and concentrated under reduced pressure resulting in the corresponding unprotected pyrrolidine, which was used in the next step without further purification. The free pyrrolidine (ca. 1 mmol) from the previous step was then taken up in CHCl3 (2.2 mL) and DIPEA (2.0 mmol) was added. The solution was added dropwise to a stirred solution of 5-chlorosulfonyl isatin (1.5 mmol) in CHCl3/THF (1:1, 15 mL) at room temperature. The resulting mixture was stirred further for 1 h and the solvent was removed under reduced pressure. After purification by flash column chromatography the target isatin sulfonamide was obtained.

According to the analysis of related databases, 132898-96-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Limpachayaporn, Panupun; Riemann, Burkhard; Kopka, Klaus; Schober, Otmar; Schaefers, Michael; Haufe, Guenter; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 562 – 578;,
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Electric Literature of 5394-18-3,Some common heterocyclic compound, 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, molecular formula is C12H12BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-[4-(4-Morpholinyl)butyl]-1H-isoindole-1,3(2W)-dione (307). A mixture of 4- bromobutylphthalimide (10.0 g, 35.4 mmol), K2CO3 (5.88 g, 42.5 mmol) and morpholine (4.6 mL, 53.1 mmol) in DMF (100 mL) was stirred at 100 0C for 8 h, cooled to 20 0C and the solvent evaporated. The residue was partitioned between EtOAc (300 mL) and water (300 mL), the organic fraction washed with water (2 x 50 mL) and brine (50 mL), dried and the solvent evaporated. The residue was purified by chromatography, eluting with EtOAc, to give phthalimide 307 (9.59 g, 94%) as a clear oil: 1H NMR delta 7.81-7.86 (m, 2 H, Harom), EPO 7.68-7.73 (m, 2 H1 Haram), 3.66-3.72 (m, 6 H, 2 x CH2O, CH2N), 2.41 (br t, J = 4.5 Hz, 4 H, 2 x CH2N), 2.35 (br dd, J = 7.6, 7.4 Hz, 2 H, CH2N), 1.69-1.76 (m, 2 H, CH2), 1.50-1.58 (m, 2 H, CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Bromobutyl)isoindoline-1,3-dione, its application will become more common.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem