Tag: M.W=100-200

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114041-16-6 as follows. COA of Formula: C10H13NO2

General procedure: Compound 8 (70.6 mg, 0.24 mmol) and 5,6-dimethoxyisoindoline(68.5 mg, 0.38 mmol) were dissolved in CH3CN (30 mL), followed by addition of K2CO3 (138.8 mg, 1.00 mmol). The mixture was heated under reflux and stirred at 90 C for 6 h. After cooling and filtration, the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate/triethyamine) = 10:10:1, v/v/v) to afford 13(56.8 mg, 59%)

According to the analysis of related databases, 114041-16-6, the application of this compound in the production field has become more and more popular.

Synthetic Route of 114041-16-6,Some common heterocyclic compound, 114041-16-6, name is 5,6-Dimethoxyisoindoline, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step e: simultaneous preparation of 1-(5,6-dimethoxyisoindolin-2-yl)-6-[4-(3-trifluoromethyl-phenyl)piperazin-1-yl]hexan-1-one, 1-isoindolin-2-yl-6-[4-(2-cyanophenyl)piperazin-1-yl]hexan-1-one and 1-isoindolin-2-yl-6-[4-(2-methyl-phenyl)piperazin-1-yl]hexan-1-one A mixture of 0.3 mmol of dicyclohexylcarbodiimide and 0.3 mmol of 1-hydroxybenzotriazole is added to a solution of acid (0.3 mmol) in 2 mL of anhydrous N,N-dimethylformamide. The mixture is left whilst stirring for four hours at 70 C. It is then cooled at ambient temperature, filtered in order to eliminate the dicyclohexylurea. Amine (0.2 mmol) is then added, then it is left for twenty hours at ambient temperature. The N,N-dimethylformamide is evaporated out in a vacuum and the crude is taken up by 2 mL of dichloromethane. It is then washed twice with 1 mL of a normal aqueous solution of soda, then with 1 mL of water. The organic phase is dried then concentrated in a vacuum. Starting from 6-[4-(3-trifluoromethyl-phenyl)piperazin-1-yl]hexanoic acid and 5,6-dimethoxyisoindoline, 1-(5,6-dimethoxyisoindolin-2-yl)-6-[4-(3-trifluoromethylphenyl)piperazin-1-yl]hexan-1-one is obtained in this way. Rf: 0.76 dichloromethane/methanol 85/15

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dimethoxyisoindoline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 20870-91-1, name is 5-Amino-1-methyl-2-oxoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20870-91-1, Computed Properties of C9H10N2O

Step 4; Preparation of (R)-[2-hydroxy-3-(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-ylamino)-propyl]-carbamic acid tert-butyl ester; 5-Amino-1-methyl-1,3-dihydro-indol-2-one (1.20 g, 7.40 mmol), (S)-oxiranylmethyl-carbamic acid tert-butyl ester (1.28 g, 7.40 mmol) and lithium trifluoromethanesulfonate (1.14 g, 7.398 mmol) in acetonitrile (10 ml) are heated at 70 C. for 1 hour. The reaction mixture is diluted with ethyl acetate, washed with water and brine, dried (Na2SO4) and evaporated. The residue is purified by flash column chromatography (70% EtOAc/Hexane) to give the title compound as a light brown solid. HPLC r.t. 3.20 min; MS for C17H25N3O4 m/z 336.4(M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1-methyl-2-oxoindoline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 20870-91-1, name is 5-Amino-1-methyl-2-oxoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20870-91-1, Safety of 5-Amino-1-methyl-2-oxoindoline

Step 4: Preparation of (5R)-2-hydroxy-3-(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-ylamino)-propionic acid methyl ester 5-Amino-1-methyl-1,3-dihydro-indol-2-one (Step 3, 1.40 g, 8.63 mmol), methyl (2R)-glycidate (0.882 g, 8.63 mmol), and lithium trifluoromethanesulfonate (1.33 g, 8.63 mmol) in acetonitrile (15 ml) are heated at 70 C. for 4 hours. The reaction mixture is diluted with ethyl acetate, washed with water and brine, dried (Na2SO4) and evaporated. The residue is purified by flash chromatography (70% EtOAc/Hexane) to give the title compound as a light brown solid. HPLC r.t. 2.44 min; MS for C13H16N2O4 m/z 265.0(M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 162100-55-2, These common heterocyclic compound, 162100-55-2, name is 5-(Trifluoromethyl)indoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 1-[2-(Pyridin-2-ylmethyloxy)pyridin-5-ylcarbamoyl]-5trifluoromethylindoline E2) Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl] carbamate (D3, 0.20 g, 0.62 mmol) in dry dimethylformamide (10 ml) was treated with 5-trifluoromethylindoline (D6, 0.12 g, 0.62 mmol) and heated at 100 C. for 1 hour. After cooling to ambient temperature, the solvent was removed in vacuo. The residue was dissolved in dichloromethane, washed with 10% aqueous sodium hydroxide solution, dried (Na2SO4) and evaporated in vacuo. The resulting oil was chromatographed on silica gel eluding with 2% methanol/dichloromethane and triturated with diethyl ether to afford the title compound (0.08 g, 31%) as an off-white solid. 1H NMR (250 MHz; d6DMSO) delta (ppm): 3.28 (2H, t, J=10), 4.19 (2H, t, J=10), 5.40 (2H, s), 6.94 (1H, d, J=10), 7.28-7.37 (1H, m), 7.40-7.58 (3H, m), 7.82 (1H, dt, J=2,7), 7.90 (1H, dd, 3=2,7), 8.00 (1H, d, J=10), 8.26 (1H, d, J=3), 8.56 (1H, d, J=7), 8.75 (1H, s).

The synthetic route of 162100-55-2 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 25128-35-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25128-35-2, name is 2,3-Dioxoindoline-7-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

(1) Preparation of methyl 7-indolo[2,3-b]quinoxalinecarboxylate A suspension of 3.96 g of 1,2-phenylenediamine and 7.00 g of 7-isatincarboxylic acid in 70 ml of acetic acid was heated under reflux for an hour. After completion of the reaction, the reaction solution was allowed to cool to room temperature, followed by addition of water, and resulting precipitate was collected by filtration. The thus obtained 7-indolo[2,3-b]quinolinecarboxylic acid and 170 ml of thionyl chloride were refluxed for 2 hours, and the excess thionyl chloride was evaporated. The residue, after addition of 250 ml of methanol, was stirred overnight. After addition of water, the resulting precipitate was collected by filtration, and purified by silica gel column chromatography to give methyl 7-indolo[2,3-b]quinoxalinecarboxylate. m.p. 251-255 C. Yield 4.04 g.

The chemical industry reduces the impact on the environment during synthesis 2,3-Dioxoindoline-7-carboxylic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 162100-55-2, name is 5-(Trifluoromethyl)indoline, A new synthetic method of this compound is introduced below., name: 5-(Trifluoromethyl)indoline

Example 22 5-Trifluoromethyl-1-(3-pyridylcarbamoyl)indoline (E22) The title compound was prepared as in the method of (Example 2) from 3-pyridylisocyanate and 5-trifluoromethylindoline (D43) to give (E22) (0.12 g, 38%) m.p. 188-189 C. NMR (DMSO-d6) delta: 3.28 (2H, t, J=8), 4.22 (2H, t, J=8), 7.31-7.37 (1H, m), 7.47-7.57 (2H, m), 7.95-8.03 (2H, m), 8.24 (1H, d, J=6), 8.75 (1H, s), 8.90 (1H, s). MH+ 308 C15 H12 N3 OF3 H+ requires 308

The synthetic route of 162100-55-2 has been constantly updated, and we look forward to future research findings.

Related Products of 13078-91-6, A common heterocyclic compound, 13078-91-6, name is 2-(Indolin-3-yl)ethanamine, molecular formula is C10H14N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tyrptamine (Ig, 6.25mmol) in DCM (lOmi) was added TFA (2m1) followed by sodium borohydride (475mg, 12.5mmol) and stirred overnight. The mixture was diluted with DCM and neutralised with sat. Na2CO3(aq). The organic phase wasseparated1 dried and concentrated to give 2-indolin-3-ylethanamine, a yellow oil. This was taken up in DCM (3Oml), triethylamine (0.90ml, 6.2mmol) added followed by BOC anhydride (1 .35g, 6.2mmol) and stirred overnight. The mixture was diluted with DCM and water. The organic layer separated, dried and concentrated onto silica. The compound was purified via column chromatography (gradient elution from 5-25%EtOAc in Pet. Ether) to give a yellow oil (684mg, 42%); 1H NMR (400 MHz,CHLOROFORM-cl) oe ppm 1.46 (s, 9K), 1.72 (m, I H), 1.90-2.04 (m, 1 H), 3.15-3.28(m, 2 H), 3.28 – 3.41 (m, 1 H), 3.58 – 3.77 (m, 1 H), 4.06 – 4.11 (m, I H), 4.57 (m, 1 H),6.90 – 6,99 (m, I H), 7.08 – 7.22 (m, 2 H), 7.37 – 8.06 (m, 1 H); LC-MS (ESl): (MW)263.2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 20870-77-3,Some common heterocyclic compound, 20870-77-3, name is 4-Chloroindolin-2-one, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENCE EXAMPLE 30 5.5 g of 4-chlorooxindole was dissolved in 80 ml of dioxane and 6.2 g of sodium borohydride was suspended in the resulting solution. 12.7 ml of trifluoroacetic acid (d=1.48) was added thereto dropwise at room temperature while stirring. After heat-refluxing the mixture for 4.5 hours, the solvent was removed therefrom under reduced pressure. Water was added to the residue and the water-insoluble materials were removed by filtration and washed with diethyl ether. The filtrate was extracted with diethyl ether and the ether layer was dried over anhydrous sodium sulfate followed by removing the solvent. The residue was distilled under reduced pressure to obtain 3.9 g of 4-chloroindoline as a colorless oily product having a boiling point of 135 C. at 10 mm Hg.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloroindolin-2-one, its application will become more common.

Reference of 120266-80-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 120266-80-0 name is 5-Aminoindolin-2-one hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-lsothiocyanato-1,3-dihydro-indol-2-one To a stirring solution of 5-amino-1,3-dihydro-indol-2-one hydrochloride (2 g, 10.83 mmol) and diisopropylethylamine (4.19 g, 32.49 mmol) in dry dichloromethane (100 ml) at 0 C under N2, thiophosgene (1.49 g, 10.83 mmol) in dichloromethane is added dropwise and stirred for 30 minutes. The reaction mixture is quenched with water (100 ml) and the layers are separated, the organic layer is washed with water (50 ml X2) and dried over anhydrous MgSO.to get the product as brown crystalline solid (2.03 g, 99.02 %); TLC: chloroform/methanol (9.5/0.5) Rf- 0.5; H-NMR (400 MHz, DMSO-d6): delta [ppm] 10.60 (s, 1H), 7.31 (s, 1H), 7.25 (d, J = 7.88 Hz, 1H), 6.82 (d, J = 8.24 Hz, 1H), 3.50 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Aminoindolin-2-one hydrochloride, and friends who are interested can also refer to it.