Tag: M.W=100-200

Synthetic Route of 25128-35-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25128-35-2 as follows.

Step 1: 2-amino-3-(methoxycarbonyl)benzoic acidTo a solution (0.4 M) of 2,3-dioxoindoline-7-carboxylic acid (1 eq.) in MeOH, HCl gas was bubbled and the reaction mixture was stirred at 800C for 2 h. After evaporation of the solvent, the resulting residue was diluted with CHCI3, washed with aqueous NaHC?3 (saturated solution), brine and dried. Evaporation of the solvent afforded a crude (MS (ES+) m/z 206 (M+H)+) that was dissolved in H2O2 (10%). To the resulting solution (0.2 M) was added an equal volume of aqueous NaOH (2.5% solution) and the reaction mixture was stirred at RT for 15 min. The reaction mixture was acidified with cone. HCl and the resulting precipitate was filtered off and washed with water to afford (88%) the title compound as white powder. 1H NMR (400 MHz, DMSO-ds, 300K) ? 3.82 (s, 3H), 6.60 (t, IH, J 7.4), 8.04 (m, 3H), 12.94 (bs, IH); MS (ES+) m/z 196 (M+H)+.

According to the analysis of related databases, 25128-35-2, the application of this compound in the production field has become more and more popular.

25369-31-7, name is 7-Nitroindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H6N2O3

To a solution of 7-nitroindolin-2-one in methanol (1.0 gm/60 ml), added Pd/C (300 mg, 30 wt %). H2 gas maintained with pressure using hydrogen gas balloon, solution stirred for 4 hours at RT. The catalyst was removed by filtration over celite. The filtrate was concentrated in vacuo to give crude product, which was washed with diethyl ether to afford compound 7-aminoindolin-2-one; YD: 76.77%; mp:248-251 C.; R1 0.6 (CHC13:MeOH:: 9.0:1.0). 1H NMR (DMSO-d6) 200 MHz, delta 3.382 (s, 2H), 4.794 (s, 2H), 6.453- 6.498 (m, 2H), 6.673 (t, J=8.0 Hz, 1H), 9.906 (s, 1H). MS (ESI): mlz 146.8 [M-H]-.

The synthetic route of 25369-31-7 has been constantly updated, and we look forward to future research findings.

Related Products of 120266-80-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120266-80-0, name is 5-Aminoindolin-2-one hydrochloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-lsothiocyanato-1 ,3-dihydro-indol-2-oneTo a stirring solution of 5-amino- ,3-dihydro-indol-2-one hydrochloride (2 g, 10.83 mmol) and diisopropylethylamine (4.19 g, 32.49 mmol) in drydichloromethane (100 ml) at 0 C under N2, thiophosgene (1.49 g, 10.83 mmol) in dichloromethane is added dropwise and stirred for 30 minutes. The reaction mixture is quenched with water (100 ml) and the layers are separated, the organic layer is washed with water (50 ml X2) and dried over anhydrous MgS04 to get the product as brown crystalline solid (2.03 g, 99.02 %); TLC: chloroform/methanol (9.5/0.5) Rf- 0.5;1H-NMR (400 MHz, DMSO-d6): delta [ppm] 10.60 (s, 1H), 7.31 (s, 1 H), 7.25 (d, J = 7.88 Hz, 1H), 6.82 (d, J = 8.24 Hz, 1 H), 3.50 (s, 2H

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Aminoindolin-2-one hydrochloride, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 16800-68-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16800-68-3, name is 1-Acetylindolin-3-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 1a (35 mg, 0.2 mmol) and 2a (52.4 mg,0.4 mmol) in DCE (3 mL) was added iodine (10 mg, 0.04 mmol). The reaction mixture was heated at 80 C for 24 h, then cooled to room temperature and quenched with saturated sodium thiosulfate. The mixture was extracted with CH2Cl2, the combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel to afford title compound.

The synthetic route of 1-Acetylindolin-3-one has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102359-00-2, Computed Properties of C9H7NO3

2-Oxo-2,3-dihydro-lH-indole-5-carboxylic acid (7 g, 39 mmol) is dissolved together with benzylalcohol (4.2 mL, 39 mmol) and 4-lambda/,lambda/-dimethylaminopyridine (1 g, 7.9 mmol) in 70 mL DCM and cooled in the ice bath. Then l-ethyl-3-(3-dimethylaminopropyl)carbo- diimide (8.3 g, 43 mmol) is added and the mixture is heated to RT for 12 h. After evaporation of the solvent the residue is taken up in a little methanol and combined with 1 N hydrochloric acid (200 mL). The precipitate formed is filtered and dried. Yield: 6.9 g (65 %) (A86).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Oxoindoline-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3, Recommanded Product: 3-Nitrophthalimide

Step 1) Synthesis of 2-carbamoyl-6-nitrobenzoic acid This moiety was synthesized using the following protocol. To a solution of potassium hydroxide (6.44 g, 114.4 mmol) in water (200 mL), was added 3-nitrophalimide (10; 10 g, 52 mmol) in portions at 0 C. The suspension was stirred at 0 C. for 3 hours, and then heated to 30 C. for 3 hours. To the solution, was added HCl (40 mL, 6N). The resulting suspension was cooled to 0 C. for 1 hour. The suspension was filtered and washed with cooled water (2*20 mL) to give 2-carbamoyl-6-nitrobenzoic acid (11; 8.5 g, 77%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalimide, other downstream synthetic routes, hurry up and to see.

Application of 56341-37-8,Some common heterocyclic compound, 56341-37-8, name is 6-Chlorooxindole, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under argon atmosphere, 3,5-bis(trifluoromethyl)phenylisocyanate(255mg, 1.0mmol) was dissolved in tetrahydrofuran(5mL). A solution of 6-chloro-oxindole(184mg, 1.1mmol) in tetrahydrofuran(5ml) and triethylamine(0.3mL) were added, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel(n-hexane:ethyl acetate=4:1) to give the title compound(172.2mg, 40.7%) as a pink solid.1H-NMR(DMSO-d6): delta 3.97(2H, s), 7.29(1H, dd, J=8.1, 2.1Hz), 7.41(1H, d, J=8.1Hz), 7.88(1H, s), 8.04(1H, d, J=2.1Hz), 8.38(2H, s), 10.93(1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Chlorooxindole, its application will become more common.

Application of 954255-04-0,Some common heterocyclic compound, 954255-04-0, name is 5,6-Difluoroindoline, molecular formula is C8H7F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5,6-difluoro-indoline 0.40g (2.58mmol),3,5-dimethoxybromobenzene 0.58 g (2.71 mmol),3% molar amount of Pd(OAc) 2 (17 mg),6% molar amount of P(t-Bu)3.HBF4 (45 mg),Sodium tert-butoxide (0.50 g, 5.16 mmol) was added to 40 mL of toluene.Heating at 110 C for 12 h,filter,The filtrate is depressurized to remove the solvent.Column chromatography (PE: CH2Cl2 = 5:1) gave 0.45 g of white crystals.The yield was 60%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoroindoline, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 39603-24-2

General procedure: Sulfonated-beta-cyclodextrin (beta-CD-SO3H) (76 mg, 0.06 mmol) was dissolved in water (5 mL) at RT by stirring to get the clear solution in 50 mL round bottom ask. Further, isatin 2 (0.31 mmol) and tryptamine 1a/isotryptamine 1b (0.31 mmol) were added to the solution under constant stirring and mixture was heated at 80 C for 8-12 h. The progress of the reaction was monitored by TLC. After completion of reaction, it was cooled to room temperature, water was added to it. The aqueous phase was extracted with ethylacetate. The organic extracts were combined, washed with brine and dried over sodium sulfate. The solvent was evaporated in vacuo and the crude product obtained was puried by column chromatography using chloroform/methanol (99:1) as an eluent furnishing the product. The spectral and analytical data of all the reported products is consistent with the previous (6c,d,f) reports.

The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.

Application of 39603-24-2, These common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (The reagents were purchased fromAdamas and used without further purification.) A dry 3-mL flask was chargedwith relevant isatin 5 (0.3 mmol), tert-butyl 2-aminoacetate hydrochloride 7(0.3 mmol) and benzophenone imine 8 (0.36 mmol). The reaction mixture wasstirred at room temperature for the corresponding time. After the completionof the reaction, the reaction mixture was directly purified by silica gelchromatography (ethyl acetate/petroleum ether = 1:4) to give product 6. Asolution of 6 in EA/TFA (10:1) was stirred in a 10-mL flask under roomtemperature for 3 h. The solvent was removed under vacuum. The residue wasrecrystallized in diethyl ether/petroleum ether to give product 9.

The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.