Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611-09-6, name is 5-Nitroindoline-2,3-dione, A new synthetic method of this compound is introduced below., Computed Properties of C8H4N2O4

General procedure: A mixture of isatin (1 mmol), reactive methylene compound(1 mmol) and 1,3-dicarbonyl compound (1 mmol)in the presence of [Sipim]Cl (0.05 g) in water (5 mL)was refluxed with stirring in an oil bath. The progress ofthe reaction was monitored by TLC. After completion ofthe reaction, the mixture was filtered and remaining waswashed with warm ethanol (3 × 10 mL) in order to separate[Sipim]Cl catalyst. After cooling the ethanol phase, theprecipitates were filtered. The crude products were purifiedby recrystallization from ethanol (95 %).

The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.

Reference of 3484-35-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3484-35-3, name is 5-Methylindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

3-Methylindole-2-carbaldehyde was prepared as described in the literature: 1) David W. M. Benzies, Pilar Matinez Fresneda and R. Alan Jones, Synthetic Communications, 16 (14), 1799-1807 (1986) and 2) Chatterjee, A. and Biswas, K. M., J. Org. Chem., 1973, 38,4002. A mixture of 5-methyl-2-oxindole (59 mg), 3-methylindole-2-carbaldehyde (56 mg) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90 C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven for overnight to give 72 mg (74% yield) of 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one. 1H NMR (360 MHz, DMSO-d6) 13.03 (s, br, 1H, NH), 10.88 (s, br, 1H, NH), 7.84 (s, 1H, vinyl), 7.71 (s, br, 1H), 6.62 (d, J=8 Hz, 1H), 7.48 (d, J=8 Hz, 7.26 (t, J=7 Hz, 1H), 7.06 (t, J=7 Hz, 1H), 7.0 (d, J=8 Hz, 1H), 6.78 (d, J=8 Hz, 1H), 2.59 (s, 3H, CH3), 2.32 (s, 3H, CH3). MS m/z 289 [M+1]+.

The synthetic route of 5-Methylindolin-2-one has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 52537-00-5, name is 6-Chloro-2,3-dihydro-1H-indole, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52537-00-5, Safety of 6-Chloro-2,3-dihydro-1H-indole

Sodium cyanoborohydride (4. [88] g, 77.8 mmol) was added to a solution of 6- chloroindoline (5.9 g, [38.] 9 mmol) in acetic acid (100 mL). Gas evolution was evident at the beginning of the reaction. After stirring for 10 h, the solution was diluted with water (100 mL) and 6 N [NAOH] was added until the pH of the reaction mixture was 12-13. The resulting mixture was extracted with [CH2CLZ] (3 x 200 mL), and the combined organic layers dried over [MGS04.] Flash column chromatography on silica gel (35% [ETOAC/HEXANES)] yielded 2.3 g (39%) of a clear liquid : 1H NMR (DMSO-d6) 8 2.87 (t, J= 8.4 Hz, 2H), 3.44 (t, [J =] 8.4 Hz, 2H), 6.45 (d, J= 1.8 Hz, 1H), 6.47 (dd, J = 1.8, 7.6 Hz, 1H), 6.96 (d, J = 7.3 Hz, 1H).

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Related Products of 1914-02-9, These common heterocyclic compound, 1914-02-9, name is 3,3-Dimethylindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3,3-dimethylindoline (204 mg, 1.386 mmol), ethyl 2-bromobutanoate (1.023 mL, 6.928 mmol), and potassium carbonate (603 mg, 4.363 mmol) in 4 mL CH3CN was stirred at 100C (oil bath) for 23 h. The mixture was extracted with 2 M HCl and CH2C12. Organic phases were concentrated and the residue was purified by preparative HPLC. Fractions containing product were partly concentrated and the residue was extracted with 1 M NaHC03and CH2C12. Organic phases were dried over MgS04, filtered, and concentrate to give ethyl 2-(3,3-dimethylindolin-l-yl)butanoate (254 mg) as an oil. LCMS m/z = 261.8 [M+l]+; NMR (400 MHz, CDC13) delta ppm 1.03 (t, J = 7.4 Hz, 3H), 1.17 (t, J = 7.1 Hz, 3H), 1.25 (s, 3H), 1.34 (s, 3H), 1.79-2.00 (m, 2H), 3.23 (d, J = 8.4 Hz, 1H), 3.41 (d, J = 8.4 Hz, 1H), 4.00-4.13 (m, 3 H), 6.41 (d, J = 7.8 Hz, 1H), 6.63-6.67 (m, 1H), 6.98-7.05 (m, 2H).

The synthetic route of 1914-02-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2913-97-5, HPLC of Formula: C10H7NO3

EXAMPLE 28B Tert-butyl (2S,3S)-2-{[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino}-3-methylpentanoate To a solution of Example 28A (12.1 g) in methanol (20 mL) was added L-isoleucine tert-butyl ester hydrochloride (13.0 g, 58 mmol), sodium cyanoborohydride (7.3 g, 116 mmol), and acetic acid (2 mL). The resulting solution was stirred for 3 hrs at 25° C. and the methanol removed under vacuum, dichloromethane (500 mL) added, and the solution washed with aqueous NaHCO3 (2*300 mL). The organic layer was concentrated to give 12.9 g of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(2-Oxoethyl)phthalimide, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1914-02-9,Some common heterocyclic compound, 1914-02-9, name is 3,3-Dimethylindoline, molecular formula is C10H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3,3-dimethylindoline (2.1 g, 14.26 mmol) and 2-bromoethanamine hydrobromide (3.215 g, 15.69 mmol) was heated at 122 C for 15 h. The mixture was dissolved in 2M HC1 and purified by preparative HPLC to give the title compound (1.9 g). LCMS m/z = 191.4 [M+H]+; H NMR (400 MHz, CD3OD) delta ppm 1.31 (s, 6H), 3.14 (s, 2H), 3.19 (t, J = 6.1Hz, 2H), 3.33 (t, J = 6.1 Hz, 2H), 6.60 (d, J = 7.9 Hz, 1H), 6.70-6.76 (m, 1H), 7.01-7.09 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,3-Dimethylindoline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3, Recommanded Product: 603-62-3

To a solution of 3-nitrophthalimide (1 g, 5.20 mmol) in dry DMF (35 ml), cooled in an ice bath, NaH (60% w/w dispersion in mineral oil, 0.250 g, 6.25 mmol) was added, followed after 15 minutes by t-butyl bromoacetate (0.845 ml, 5.73 mmol). After stirring for 1 hour at room temperature, the mixture was poured into water and the resulting precipitate was washed with water and with a little amount of Et2O; after drying, tert-butyl 2-(4-nitro-1,3-dioxoisoindolin-2-yl)acetate was obtained (1.44 g, 4.70 mmol, 90% yield, MS/ESI+ 328.9 [MNa]+).

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1914-02-9, name is 3,3-Dimethylindoline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1914-02-9

A mixture of 3,3-dimethylindoline (103 mg, 0.700 mmol), potassium carbonate (288 mg, 2.084 mmol), and 2-bromopropanenitrile (303 mu^, 3.506 mmol) in 2 mL CH3CN was stirred at 80C (oil bath) over night. The mixture was purified by preparative HPLC. Fractions containing product were partly concentrated and residue was extracted with 1 M NaHC03and CH2C12. Organic phases were dried over MgS04, filtered, and concentrated to give 2-(3,3-dimethylindolin-l-yl)propanenitrile (105 mg). LCMS m/z = 201.2 [M+l]+; NMR (400 MHz, CDC13) delta ppm 1.26 (s, 3H), 1.40 (s, 3H), 1.63 (d, J = 7.3 Hz, 3H), 3.05 (d, J = 8.2 Hz, 1H), 3.25 (d, J = 8.2 Hz, 1H), 4.57 (q, J = 7.3 Hz, 1 H), 6.57 (d, J = 7.9 Hz, 1H), 6.83-6.87 (m, 1H), 7.06 (dd, J1=7.4 Hz, J2= 0.8 Hz, 1H), 7.12-7.16 (m, 1H).

According to the analysis of related databases, 1914-02-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22190-33-6, name is 5-Bromoindoline, A new synthetic method of this compound is introduced below., name: 5-Bromoindoline

Step 2. tert-Butyl-5-bromoindoline-1-carboxylate (BI12); To a stirred solution of 5-bromo-indoline (3.0 g, 15 mmol) in acetonitrile (100 ml), was added DMAP (0.185 g, 1.522 mmol) and di-tert-butyl dicarbonate (3.98 g, 18.3 mmol) and the reaction was stirred at RT for 16 h. The reaction mixture was concentrated on reduced pressure to obtain a residue which was diluted with diethyl ether and washed with water and brine solution (2×). The combined ether layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product as a off-white solid, which was used in the next step without further purification (3.0 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., name: 5-Aminoisoindoline-1,3-dione

Potassiumhydroxide (0.35 g,6.17 mmol) was added to a solution of 4-aminophthalimide 10 (1.00 g, 6.17 mmol) in dimethylformamide(30 mL) and the mixture was stirred at ambient temperature for 2 h. Iodomethane (0.88 g, 6.17 mmol) wasadded and it was stirred for another 18 h at the same temperature. Water (50 mL) and ethyl acetate (50 mL)was added and the resulting phases were separated. The organic phase was washed with brine, driedover sodium sulfate and concentrated in vacuum. Purification by chromatography on silica gel (Gradient:0-100% ethyl acetate in cyclohexane) afforded the title compound 11a as a yellow solid (1.00 g, 92% yield):1H-NMR (DMSO-d6): delta = 7.46 (d, J = 8.24 Hz, 1H), 6.90 (d, J = 2.00 Hz, 1H), 6.77 (dd, J = 8.24 Hz, 2.00 Hz,1H), 6.42 (br. s, 2H), 2.94 (s, 3H) ppm. 13C-NMR (DMSO-d6): delta = 168.87, 168.57, 155.27, 135.10, 125.17,117.33, 116.84, 107.42, 23.83 ppm. MS (m/z): 177 [M+ H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.