Tag: M.W=100-200

Reference of 611-09-6, A common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a well-stirred solution of isatin and malononitrile(1 mmol each) in ethanol (95%, 4 mL) was added dimedone,4-hydroxycoumarin, 4-hydroxy-N-methylquinolin-2-one,or 2-methyl-pyrazol-2-one [generated in situ from ethylacetoacetate and hydrazine hydrate, 1 mmol each]. To thissolution was added THAM (30 mol %) and stirring wascontinued at ambient temperature. Upon completion of thereaction (TLC), water (5 mL) was added and stirring wascontinued for 10 min more. Resultant solid product wasfiltered, washed repeatedly with water, and dried. The dried solid was washed thrice with hexaneechloroformmixture (1:1, v/v) and dried again. Resultant product didnot require any further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39603-24-2, Computed Properties of C10H9NO2

General procedure: A solution of an isatin (3) (1 mmol), a C-H acidderivative (2) (1 mmol), and naphthalen-1-amine (1)(1 mmol) was heated at 80 C in acetic acid (5 mL)for 24 h. After completion of the reaction as indicatedby TLC (MeOH/AcOEt, 1:4), the residue wasfiltered and washed successively with gl. acetic acid andCHCl3 (3 × 10 ml). The crude product thus obtainedwas crystallized from MeOH or EtOH and dried atroom temperature. The final product was obtained as a powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dimethylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference of 3485-84-5, These common heterocyclic compound, 3485-84-5, name is N-Vinylphthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a reactor, 2 g of the compound obtained in Step A, 2 eq. of N-vinylphthalimide, 1.25 eq. of diisopropylethylamine and 0.05 eq. of palladium tetrakis(triphenylphosphine) are introduced into toluene and heated at reflux. The reaction is continued at reflux for 12 hours and then the reaction mixture is cooled to ambient temperature. Ethyl acetate is added, and then washings with water and IN HCl solution are carried out. After evaporating off the solvents, the residue obtained is purified by chromatography on silica gel (eluant:dichloromethane/heptane 1/1, and then dichloromethane) to yield the title product in a yield of 80% and with a chemical purity of more than 95%.Melting point: 146 C.

The synthetic route of 3485-84-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., SDS of cas: 3676-85-5

Example 250Preparation of rac (2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid (1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-amide To a stirred solution of thionyl chloride (2 mL), rac (2R,3S,4R,5S)-3-(3-Chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid (110 mg, 0.24 mmol) was added and the mixture was stirred at rt for 2 hrs. The excess thionyl chloride was removed and the residue was dissolved in methylene chloride (5 mL) and 5-amino-isoindole-1,3-dione (Aldrich, 0.30 mmol) was added followed by the addition of triethylamine (0.2 mL). The mixture was stirred overnight. The solvent was removed and the residue was purified on an ISCO machine (24 g column, eluent, 40-80% EtOAc/hexanes) to give a pale yellow solid. 10 mg.MS (ES+) m/z Calcd: [(M+H)+]: 611, found: 611

The synthetic route of 3676-85-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, A new synthetic method of this compound is introduced below., Safety of N-(2-Oxoethyl)phthalimide

A series of acceptor aldehydes was used to study the scope of the reaction. Results of reactions with oc,a-disubstituted aldehyde acceptors are shown in Table 7, hereinafter.Reactions with 2-ethylbutyraldehyde, cyclohexanecarboxaldehyde (c-CgHnCHO) , andcyclopentanecarboxaldehyde (C-C5H9CHO), providedaldol products at 4 °C and these product aldehydes were transformed to the corresponding methyl esters in good yields (62-75 percent from Compound 1) with high enantioselectivities (94-98percent ee) (entries 1, 3, and 4). The diastereoselectivities of the aldol reactions were also high (dr = >10:1 to 15:1) . The diastereomeric ratio of the aldol products decreased by epimerization at C2 when the compounds were stored or when they were purified by silica gel columnchromatography. [See (9) (b) Notz et al. , J”. Org. Chem. 2003, 68, 9624. (c) Cordova et al., J. Am. Chem. Soc. 2002, 124, 1866.] The column chromatography did not completely separate the anti-and syn-isomers of Compound 3 from each other.The reaction with di-n-butylacetaldehyde, an aldehyde bearing a bulky group, was slow at 4 °C and was performed at room temperature (rt; entry 2). This case also provided the desired product with high enantioselectivity (93percent ee). The reaction with a-dimethoxy acetaldehyde, available in aqueous solution, afforded the desired aldol product with low diastereoselectivity, but 86percent ee in the presence of water (entry 5).Thus, the aldol reaction of Compound 1 was efficient for the synthesis of a broad range of enantiomerically enriched y-branched-p-hydroxy-ot-amino acid derivatives. Results for reactions illustrated in Scheme 2 are shown in Table 7, again only Compound 1 acted as the donor.Table 7aCompound 2entryRproductdr (anti:syn)D1CHEt22b>10:12’CH(nBu)22c10:13c-CsH-j-i2d15:14C-C5H92e14:15″CH(OMe)22f5:1Compound 3entryRproductdr (antksyn)”ee (percent)6Yield (percent)c1CHEt23b>10:194752’CH(nBu)23c7:193683C-CgHn3d5:198734C-C5H93e16:1989625hCH(OMe)23f1:186 (syn, 68)69a Unless otherwise noted, a mixture of Compound 1 (2 mmol), acceptor aldehyde (10-20 mmol), and L-proline(0.6 mmol) in N-methylpyrrolidone (NMP) (1 mL) was stirred at 4 °C for 16-48 hours for the aldol reaction. See Scheme 2. b Diastereomeric ratio of Compound 2 determined by XH NMR analysis of the reaction mixture without purification. c Isolated yields of Compound 3 (from Compound 1). d Diastereomeric ratio of Compound 3 after purification using silica gel column chromatography, determined by “”H NMR analysis. e Enantiomeric excess of anti-Compound 3 determined by chiral-phase HPLC analysis, except noted. f The reaction was performed at rt. 9 The ee of anti-Compound 2e was determined by HPLC analysis of the corresponding oxime prepared with O-benzylhydroxylamine. h The reaction mixture included water.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 61-70-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61-70-1, name is 1-Methylindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried reflux tube equipped with a magnetic stir bar and a Teflon stopcock was charged with aryl halide (1 mmol), oxindole (1 mmol),potassium carbonate (1.1 mmol), catalyst nanoparticles (0.05 mmol)and 1,4-dioxane (2 ml) and heated at 70 C. The mixture was vigorously stirred under these reaction conditions and completion of the reaction was monitored by TLC (EtOAc: n-hexane, 25:75). After completion of the reaction, the reaction mixture was cooled to room temperature, the magnetic nanoparticles of the catalyst were collected using a magnet. Ethyl acetate (5 mL) and water (10 mL)were added to the mixture in the next step. The aqueous layer was furtherextracted by ethyl acetate (2*5 mL). The combined organic layerswere washed with saturated brine, dried over CaCl2, filtered, and concentrated to give a residue which was purified by recrystallization from ethanol and water or by column chromatography on silica gelusing EtOAc: n-hexane, 1:7.

The chemical industry reduces the impact on the environment during synthesis 1-Methylindolin-2-one. I believe this compound will play a more active role in future production and life.

Electric Literature of 954255-04-0,Some common heterocyclic compound, 954255-04-0, name is 5,6-Difluoroindoline, molecular formula is C8H7F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 39 Adamantan-1-yl-(5,6-difluoro-2,3-dihydro-indol-1-yl)-methanone In analogy to the procedure described for the synthesis of adamantan-1-yl-(3,4-dihydro-1H-isoquinolin-2-yl)-methanone (example 1) the title compound was prepared from 5,6-difluoroindoline and adamatanecarbonyl chloride as light brown solid. MS(m/e): 318.3 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoroindoline, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102359-00-2, Product Details of 102359-00-2

A mixture of 5-carboxy-2-oxindole (113 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90 C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 75 mg (58% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid (piperidine salt). 1H NMR (360 MHz, DMSO-d6) 13.0 (s, br, 1H, NH), 8.35 (d, J=1.5 Hz, 1H, H-4), 7.91 (s, 1H, vinyl), 7.82 (dd, J=1.5 and 8 Hz, 1H, H-6), 7.63 (d, J=8 Hz, 1H), 7.49 (d, J=8 Hz, 1H), 7.26 (t, J=7.5 Hz, 1H), 7.06 (t, J=7.5 Hz, 1H), 6.8 (d, J=8 Hz, 1H), 2.91 (t, 4H, piperidine), 2.6 (s, 3H, CH3), 1.6 (m, 4H, piperidine), 1.54 (m, 2H, piperidine).

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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4770-32-5 as follows. Formula: C10H11NO2

To a solution of the title compound from step 3 (3.0 g, 16.95 mmol) in AcOH (25 mL) was added a solution of NBS (3.01 g, 16.95 mmol) in AcOH (25 mL) slowly at 10C-20C. The mixture was stirred at that temperature for 1 hr. It was then poured over water (50 ml) and extracted with CH2CI2 (200 ml x 5). The combined organic phases were washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (PE: EA=10: 1-1: 1) to provide the title compound (1.10 g, 25% yield) as a solid. H NMR (DMSO-d6, 400 MHz) delta 9.90 (s, 1 H), 8.14 (s, 1 H), 6.83 (s, 1 H), 4.05 (t, J=8.4 Hz, 2 H), 3.04 (t, J = 8.4 Hz, 2 H), 2.11 (s, 3 H). LCMS: 256.0, 258.0 [M+H]+.

According to the analysis of related databases, 4770-32-5, the application of this compound in the production field has become more and more popular.

Related Products of 17630-75-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17630-75-0, name is 5-Chloro-2-oxindole belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 5-chlorooxindole (6.98 g, 41.6 mmol), 3,5-dimethyl-1H-pyrrole-2-carboxaldehyde (5.12 g, 41.6 mmol) and piperidine (410 muL, 4.16 mmol) in 200 mL of EtOH was heated at reflux for 8 h. The reaction mixture was cooled to room temperature and filtered to give the title compound (4.50 g, 40%) as a red/orange solid.

The synthetic route of 5-Chloro-2-oxindole has been constantly updated, and we look forward to future research findings.