Tag: M.W=100-200

3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(2-Hydroxyethyl)isoindoline-1,3-dione

0.50 g of N-(2-hydroxyethyl)phthalimide, 10 mL of thionyl chloride, 2 drops of DMF, reflux for 5.0 h.Reaction is complete, cooling, 10% NaHCO33The solution was neutralized to neutral and extracted with ethyl acetate. The organic layer was dried and desolvated to give a solid. The crude product was recrystallized to give a pale yellow solid (0.46 g), yield 83.9%.

The synthetic route of 3891-07-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-40-7, name is 5-Nitroisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Nitroisoindoline-1,3-dione

4-Nitrophthalimide (LOOGR) was taken into a beaker and dissolved using 300ML of dimethylformamide and 400ML of methanol. The solution was transferred into a 1L hydrogenation kettle and 20gr of wet Raney nickel catalyst was charged into the kettle. Hydrogenation was carried out initially at 20-40psi and 25-30C until the exothermic nature was over. Hydrogenation was further continued at 40-60psi pressure and 40-50C. After checking the completion of reaction by TLC, catalyst was removed by filtration and the solvents distilled off from the reaction mixture at 50-60C. The residue thus obtained was suspended in water (500ML) and filtered off to get a bright yellow crystalline compound of 4-aminophthalimide (78gr, 92.5%). Melting point: 294-5C.

According to the analysis of related databases, 89-40-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141452-01-9 as follows. SDS of cas: 141452-01-9

Preparation of Intermediate 1-(4′-Trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (I-5b) 4′-Trifluoromethyl-biphenyl-2-carboxylic acid (4.51 g, 16.9 mmol) and 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester I-5a (3.0 g, 16.9 mmol) were dissolved in DCM (50 ml). PyBroP (8.4, 18 mmol) and hunig’s base (2.58 g, 20 mmol) were added to the above mixture the reaction mixture was stirred overnight. PyBroP (4 g) was added to the reaction mixture and the reaction mixture was stirred overnight.The reaction mixture was diluted with DCM (200 ML) and washed with a saturated solution of NaHCO3 (100 ml*3), HCl (1N, 150 ml*2).The organic layer was collected and dried (Na2SO4).The solvent was removed under reduced pressure and the residue was purified by flash chromatography to provide the desired product 3.5 g.

According to the analysis of related databases, 141452-01-9, the application of this compound in the production field has become more and more popular.

Reference of 89-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-40-7, name is 5-Nitroisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: N-Methylation of phthalimide derivative M11 was obtained by nucleophilic displacement of iodide from alkyl iodide by deprotonated phthalimide. A mixture of appropriate phthalimide, iodoalkane, and potassium carbonate in DMF was stirred for 6-10 h at 70-110 C. After completion, the mixture was poured into an ice/water mixture. The aqueous phase was extracted with dichloromethane. The combined organic phase was washed with 0.1 HCl, brine and was dried over anhydrous sodium sulfate. The desired N-alkylated product was isolated using flash column chromatography.

The synthetic route of 5-Nitroisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.

Reference of 317-20-4, These common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of isatin (0.15 g, 1 mmol), 5,5-dimethylcyclohexane-dione (0.14 g, 1 mmol), barbituric (0.13 g, 1 mmol) in gluconic acid aqueous solution (3 ml) was stirred at 100 C. The reaction progress was monitored by thin-layer chromatography. After completion of the reaction, the reaction mixture was cooled to room temperature. Then, the precipitated product was filtered and washed with water. The crude product was crystallized from ethanol to give 4a.

The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 84575-27-9, These common heterocyclic compound, 84575-27-9, name is 7-Methoxyindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In another example, N-methyl-7-methoxyindoline-2,3-dione (S5) is prepared according to Scheme 1h: To a solution of 7-methoxyindoline-2,3-dione (SM5) (16.7 g, 94.3 mmol, 1.0 equiv) and N,N-dimethylformamide (205 mL) was added sodium hydride (4.41 g, 104 mmol, 60% dispersion in mineral oil, 1.1 equiv) at rt. After 10 min, iodomethane (6.45 mL, 104 mmol, 1.1 equiv) was added, and the reaction mixture was maintained at rt for 4 hr. The reaction mixture was then poured into ice water (800 mL) and the resulting dark red precipitate was collected by vacuum filtration. The solid was washed with water (2*300 mL), redissolved in dichloromethane (700 mL), dried over MgSO4, and concentrated to provide isatin S5 (16.1 g, 90%) as a dark red solid: 1H NMR (500 MHz, CDCl3) delta 7.22 (dd, J=7.4, 1.1, 1H), 7.16 (dd, J=8.3, 1.0, 1H), 7.04 (dd, J=8.3, 7.4, 1H), 3.90 (s, 3H), 3.50 (s, 3H), 0.95 (s, 3H); HRMS-ESI (m/z) [M+Na]+ calcd for C10H9NO3Na, 214.0480; found, 214.0482.

Statistics shows that 7-Methoxyindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 84575-27-9.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56341-37-8, name is 6-Chlorooxindole belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 6-Chlorooxindole

General procedure: To the mixture of optionally substituted 6-chlorooxindole (5.0 mmol) and 3-chloro-2-fluorobenzaldehyde (2.4 g, 15 mmol) (Oakwood) in methanol (50 mL) was addedpiperidine (Aldrich) (1.7 g, 20 mmol) dropwise. The mixture was then heated at 50 Cfor 3 h. After cooled to 4 C, the mixture was filtered and resulting precipitate wascollected, washed with cold methanol, dried to give the desired product.(E)-6-chloro-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-indol-2-one 13.1 (R3a = H,R3b = H, R3c = H): a yellow solid (Yield, 84%); 1H NMR (300 MHz, DMSO-d6) 10.88 (br.s., 1H), 7.73 (q, J = 7.41 Hz, 2H), 7.56 (s, 1H), 7.34 – 7.43 (m, 1H), 7.17 (d, J = 8.10 Hz,1H), 6.87 – 6.97 (m, 2H) ppm.

The synthetic route of 56341-37-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32692-19-6, name is 5-Nitroindoline, A new synthetic method of this compound is introduced below., Safety of 5-Nitroindoline

Example 23 (S)-3,5-Dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)- phenyl)-2-(2-(5-(methylsulfonamido)indolin-1 -yl)acetoxy)ethyl)pyridine1 -oxide (Compound 131 ) Scheme 23 Step 1 : Preparation of benzyl 2-(5-nitroindolin-1 -yl)acetate (127) To a solution of 5-nitroindoline (1 g, 6.09 mmol) in dry DMF (20 ml), K2C03 (1 .094 g, 7.92 mmol) and benzyl 2-bromoacetate (1 .242 ml, 7.92 mmol) were added and the resulting suspension was heated at 65C for 2 hours. The mixture was cooled to room temperature, diluted with ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulfate and the solvent was removed. The residue was purified by flash chromatography on silica gel column (DCM:petroleum ether = 60:40) affording benzyl 2-(5-nitroindolin-1 -yl)acetate (0.782 g, 2.504 mmol, 41 % yield). MS/ESI+ 312.9 [MH] +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 22190-33-6, name is 5-Bromoindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Bromoindoline

Combine 5-bromoindoline (3.56 g, 18 mmol) and Et3N (1.92 g, 19 mmol) in CH2Cl2 (40 ml). Cool in an ice bath and add Boc2O (4.14 g, 19 mmol). Allow to warm, stir 2 h and add more Boc2O (0.50 g). Stir 2 h and wash with 1N HCl, then with 1N NaHCO3. Dry (MgSO4) and concentrate. Heat the solid with hexane, allow to cool, and filter to obtain the carbamate as off-white crystals, m.p. 124-6 C.

The synthetic route of 5-Bromoindoline has been constantly updated, and we look forward to future research findings.

Reference of 3891-07-4,Some common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, molecular formula is C10H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure for the Synthesis of N-(2-(benzyloxy)ethyl)-dinitrobenzamide (B2) To a solution of 2-(2-hydroxyethyl)isoindoline-1,3-dione (1.17 mmol) in dimethylformamide (10 mL) was added sodium hydride (2.34 mmol) and a benzyl bromide (1.40 mmol) at 0 C. and the resulting mixture was stirred at room temperature. After stirring overnight, distilled water (50 mL) was added and the resulting precipitate was collected by filtration to afford B1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Hydroxyethyl)isoindoline-1,3-dione, its application will become more common.