Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32372-82-0, name is Isoindoline hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: Isoindoline hydrochloride

To concentrated sulphuric acid (3 mL) at -10C was added isoindoline hydrochloride (1.569 g). The mixture was stirred at -10C for 15 min. Fuming nitric acid (3 mL) was added drop-wise. The resulting mixture was stirred for 35 min at room temperature and then heated up and stirred at 50 C for 35 min. After cooling to room temperature, the mixture was diluted with ethyl acetate (5 mL) and poured onto ice-water. The resulting precipitate was collected, washed with small amount of ethyl acetate and dried to afford 5-nitroisoindoline hydrosulfate 1 (1.644 g, 62.7%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 480-91-1, These common heterocyclic compound, 480-91-1, name is Isoindolin-1-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A stirred mixture of 79D (4.6 g, 8.64 mmol), isoindolin-1-one (1.15 g, 8.64 mmol), Pd2(dba)3 (791 mg, 0.864 mmol), Cs2CO3 (8.44 g, 25.92 mmol) and Xantphos (700 mg, 1.21 mmol) in 1,4-dioxane (150 mL) was heated to 100 C. overnight. The reaction mixture was allowed to cool to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica column chromatography (1%-5% MeOH in DCM) to give 79E (2.6 g, 56% yield) as a white solid: 1H NMR (400 MHz, DMSO-d6) delta 8.54 (d, J=8 Hz, 1H), 8.05 (t, J=7.6 Hz, 1H), 7.99 (d, J=6.8 Hz, 1H), 7.79 (d, J=7.6 Hz, 1H), 7.66 (t, J=7.2 Hz, 1H), 7.57-7.48 (m, 3H), 7.22 (t, J=7.6 Hz, 1H), 7.13-7.04 (m, 4H), 5.19 (d, J=7.2 Hz, 1H), 5.03 (d, J=17.6 Hz, 1H), 4.56 (d, J=17.6 Hz, 1H), 4.11 (dd, J=10.4 Hz, 3 Hz, 1H), 3.95 (d, J=9.2 Hz, 1H), 3.12-2.93 (m, 3H), 2.81-2.75 (m, 1H), 0.80 (s, 9H); ESI m/z 586.1 [M+H]+.

Statistics shows that Isoindolin-1-one is playing an increasingly important role. we look forward to future research findings about 480-91-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H9NO3

General procedure: To a double-necked round bottom flask (100mL), equipped with a condenser, it was added a mixture of KI (1.5mmol), P2O5 (1.5mmol) and the desired alcohol (1mmol) in DMF (5mL). The reaction mixture was stirred at r.t. for 30min. Next, the considered nucleobase (1mmol), K2CO3 (1mmol) and Et3N (1mmol) were added and the reaction mixture was heated to reflux for a further 6.5-10.5h (until TLC indicated no further progress in reaction, Table5). The solvent was then evaporated at reduced pressure, and the remaining foam was dissolved in chloroform (150mL) and washed with water (2×150mL). The organic layer was dried on Na2SO4 (1g) and evaporated. The product was purified using short column chromatography on silica gel eluting with proper solvents.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3891-07-4.

Synthetic Route of 496-12-8, The chemical industry reduces the impact on the environment during synthesis 496-12-8, name is Isoindoline, I believe this compound will play a more active role in future production and life.

Step 1: Boc-4-Oxo-proline methyl ester (100 mg, 0.41 mmol) and isoindoline (51 pL, 0.43 mmol) were dissolved in DCE (1 .5 mL) and acetic acid (25 pL, 0.41 mmol) added. After 1 hour, NaBH(OAc)3 (261 mg, 1 .23 mmol) was added and the reaction mixture stirred at room temperature overnight. The reaction mixture was diluted with sat. aq. NaHCO3 and extracted with DCM. The combined organics were passed through a phase separator and the solvent removed to give acrude product which was purified by column chromatography (Biotage, 1 Og SNAP, 0-80% EtOAc/ihexane) to give (25,4R)-4-(1 ,3-dihydro-isoindol-2-yl)-pyrrolidine-1 ,2-dicarboxylic acid 1-tert- butyl ester 2-methyl ester (0.1 3g, 92%) as a brown oil.AnalpH2_MeOH_4MIN: Rt: 1.99 mi mlz 347.3 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 7147-90-2, name is 5-Chloroisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H4ClNO2

General procedure: (0.107) Intermediate 4 (0.001 mol) was dissolved in 15 ml of N ‘N-dimethylformamide solution, anhydrous potassium carbonate (0.00 mol) was added, methyl iodide (0.0015 mol) or benzyl chloride (0.0015 mol)The mixture was stirred at room temperature for 5 hours. The filtrate was distilled off and the solvent was distilled off, and the residue was recrystallized from methanol to give the intermediate compound 17. 17a: pale yellow solid, yield 72.4%

The synthetic route of 5-Chloroisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 15861-23-1, name is Indoline-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H8N2

To a solution of indoline-5-carbonitrile (1 10 mg, 0.75 mmol) in 2.5 mL of MeOH was added tert-butyl 3-oxopyrrolidine-l-carboxylate (166 mg, 0.90 mmol) and HO Ac (0.1 1 mL, 1.88 mmol) subsequently. After stirring at room temperature for 10 minutes, NaCNBH3 (57 mg, 0.90 mmol) was added and the mixture was then stirred at ambient temperature for 2 days. The volatiles were removed under vacuum. The residue was diluted with EtOAc, then washed with 1 N NaOH solution and brine, dried over Na2S04, and evaporated in vacuo to afford the crude title compound for the next step use without further purification.

The synthetic route of Indoline-5-carbonitrile has been constantly updated, and we look forward to future research findings.

Application of 1504-06-9, The chemical industry reduces the impact on the environment during synthesis 1504-06-9, name is 3-Methyloxindole, I believe this compound will play a more active role in future production and life.

-Methyloxindole (1.5 g, 10.2 mmol) and lithium chloride (1.26 g, 30 mmol) was dissolved in THF (100 mL). The solution was then cooled to -78 C. and n-butyllithium (4.2 mL, 2.5 M in hexanes, 10.5 mmol) was added slowly over a 15 minute period. Ethyl iodide (4.16 mL, 50 mmol) was added and the mixture was allowed to warm to room temperature. After 24 hours, the mixture was poured into water and extracted with ethyl acetate, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography (SiO2, Hexane/ethylacetate 9/1 then 8/2) gave 3-ethyl-3-methyl-1,3-dihydro-2H-indol-2-one (0.750 g, 25%): HRMS [M+H]+176.1076

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyloxindole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19727-83-4, name is 6-Nitroindoline, A new synthetic method of this compound is introduced below., Computed Properties of C8H8N2O2

PREPARATION 5 1-(3-Chloropropionyl)6-nitroindoline 8.2 g (50 mmol) of 6-nitroindoline (prepared as described in Preparation 4) were dissolved in 100 ml of acetone, and 6.35 g (50 mmol) of 3-chloropropionyl chloride were added to the solution while ice-cooling, which resulted in the reaction mixture becoming a suspension. This suspension was stirred at room temperature for 1 hour, after which it was heated under reflux for 2 hours, and formed a solution. The resulting solution was cooled to room temperature, and then 10% w/v aqueous hydrochloric acid was added, and the precipitated crystals were collected by filtration. The crystals thus obtained were dried over phosphorous pentoxide in a desiccator under reduced pressure by means of a vacuum pump overnight to obtain 12.7 g (50 mmol) of the title compound as crystals, melting at 127-128 C. (yield: 100%). 1 H Nuclear Magnetic Resonance (200 MHz, CDCl3) delta ppm: 2.95 (2H, triplet, J=6.7 Hz); 3.32 (2H, triplet, J=8.6 Hz); 3.93 (2H, triplet, J=6.7 Hz); 4.22 (2H, triplet, J=8.6 Hz); 7.30 (1H, doublet, J=8.2 Hz); 7.93 (1H, doublet of doublets, J=2.0 & 8.2 Hz); 9.03 (1H, doublet, J=2.0 Hz). Mass Spectrum (m/z): 254 (M+), 218, 164, 118.

The synthetic route of 19727-83-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60434-13-1, name is 5-Chloro-1-methylindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 60434-13-1

General procedure: A solution of N-methylisatin (322 mg, 2.0 mmol), indole (258 mg, 2.2 mmol), and K2CO3 (138 mg, 1.0 mmol) in aqueous DMF (H2O/DMF, 2:1, 5.0 mL) was heated to 50 oC for 3 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 1:1), 3-hydroxy-3-(1H-indol-3-yl)-1-methylindolin-2-one (1m) was obtained as a white solid, 340 mg (61%).1 To a stirred solution of 1m (278 mg, 1.0 mmol) in DMF (3.0 mL) was added t-BuOK (125 mg, 1.1 mmol) and iodomethane (158 mg, 1.1 mmol) successively at 0 oC. The reaction mixture was stirred at room temperature for 2 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 3:1), compound 1a was obtained as a white solid, 185 mg (63%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 60434-13-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52351-75-4, name is 6-Methoxyindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H7NO3

Example 12 (S)-3,5-Dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)- phenyl)-2-(2-(6-methoxy-2,3-dioxoindolin-1 -yl)acetoxy)ethyl)-pyridine 1 -oxide (Compound 64) Scheme 12 Step 1 : Preparation of tert-butyl 2-(6-methoxy-2,3-dioxoindolin-1 – yl)acetate (62) To a solution of 6-methoxyindoline-2,3-dione (350 mg, 1 .976 mmol) in acetonitrile (10 ml), K2C03 (328 mg, 2.371 mmol) and tert-butyl 2-bromoacetate (350 muIota, 2.371 mmol) were added and the mixture was reacted at room temperature overnight. The insoluble inorganic salts were filtered off and the solvent was evaporated obtaining the crude title compound (550 mg, 1 .888 mmol, 96% yield). MS/ES 292.1 [MH] +. The crude was used in the next step without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52351-75-4.