Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, Application In Synthesis of Isoindoline

A mixture of 31 -1 (100 mg, 0.306 mmol), isoindoline (47 mg, 0.398 mmol) and HATU (232 mg, 0.611 mmol) in THF (10 mL) was stirred for 10 min at room temperature. DIPEA (99 mg, 0.764 mmol) was added and the reaction mixture was stirred overnight. The volatiles were evaporated and the resulting residue was partitioned between ethyl acetate (10 mL) and water (10 mL). The organic layer was separated and washed with brine (3 X 10 mL), dried over Na2SO4 and concentrated under vacuum. The resulting residue was purified on silica gel column chromatography eluting with dichloromethane/methanol (100: 1) to afford 31 -2 (180 mg, 70%) as a white solid. LRMS: calc 428.2 and found: 429.1 [M+l].General conditions for step 1: amine, BOP, TEA in DMF .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 102359-00-2

General procedure: Aldehydes (1-5) (0.2 mmol) and oxindoles (7-11) (0.2 mmol) were dissolved in alcohol MeOH, EtOH, or tert-BuOH (1.5 ml). 3 droplets of piperidine were added to the solvents and the reaction mixture was stirred in a sealed vial at 60 – 70 C for 2 – 8 hours.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 102359-00-2.

Electric Literature of 7477-63-6, These common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A magnetically stirred mixture of naphthalene-2-amine (1.0mmol), isatin (1.0 mmol), dialkyl acetylenedicarboxylate (1.2 mmol) andanhydrous antimony trichloride (0.10 mmol) in dry acetonitrile (3 mL) taken ina 10 mL round bottom flask fitted with a reflux condenser under argonatmosphere and was refluxed for 5 h. After completion of the reaction, thereaction mixture was allowed to cool, quenched with water (10 mL) and extractedwith DCM (3 x 20 mL). The combined organic extracts were dried over anhydrousNa2SO4, filtered and volatiles were removed in vacuo. Thecrude residue was purified by column chromatography over silica gel (100-200mesh), eluting with 25 percent ethyl acetate in petroleum ether to afford compound (4).

Statistics shows that 7-Chloroisatin is playing an increasingly important role. we look forward to future research findings about 7477-63-6.

6341-92-0, name is 6-Chloroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 6-Chloroisatin

D. 6-Chloro-2-oxindole Reaction of 36.2 g of 6-chloroisatin with hydrazine hydrate followed by sodium ethoxide in ethanol, substantially according to C above, afforded 14.2 g of 6-chloro-2-oxindole, mp 196-198 C.

The synthetic route of 6341-92-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 102359-00-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102359-00-2 name is 2-Oxoindoline-5-carboxylic Acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 4 (1.77 g, 10 mmol) in 120 mL ofdichloromethane and 10 mL of DMF was added 4-methylmorpholine or DIEA (10 mL), TBTU (4.81 g, 15mmol) and aniline derivatives (11 mmol). The mixture wasstirred under room temperature for 18 h and washed in turnwith 5% sodium carbonate solution, 5% citric acid solutionand saturated sodium chloride solution. After dried byanhydrous sodium sulfate, the organic layer was evaporatedto dryness. The residue was purified with flash chromatography(CH2Cl2:CH3OH, 50:1) to afford intermediates 5a-5l, which were used in the next step in short time. To asolution of compounds 5a-5l (1.0 mmol) in 10 mL methanolwas added piperidine (30 muL) and 1H-pyrrole-2-carbaldehyde/furan-2-carbaldehyde (1.0 mmol). The mixturewas stirred at 60 C for 5 h and cooled to room temperature.After kept in fridge overnight, the target compounds 6a-6land 7a-7l were obtained in high yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Oxoindoline-5-carboxylic Acid, and friends who are interested can also refer to it.

Synthetic Route of 20870-79-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20870-79-5, name is 5-Nitroindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows.

The 5-nitro-2-oxindole 1 (1 .00 g, 5.61 mmol) was hydrogenated in EtOH (70 mL)in the presence of 10% Pd-C (315 mg, 2.97 mmol) for 4h at room temperature.Then the catalyst was filtered off through Celite, the Celite rinsed with additional EtOH and the solution was evaporated, to give 2 as a brown solid (698 mg, 4.71 mmol, 84% yield).1HNMR (400 MHz, DMSO-d6): 6 3.30 (5, 2H, CH2); 4.62 (br s, 2H, NH2); 6.37(dd, 1H, J= 2.2, 8.2 Hz, Ar); 6.48-6.50 (m, 2H, Ar); 9.90 (br s, 1H, NH) ppm.Anal. Calcd for C8H8N20: C, 64.85%; H, 5.44%; N 18.91%; Found: C, 65.03%;H, 5.49%; N, 18.83%

The chemical industry reduces the impact on the environment during synthesis 5-Nitroindolin-2-one. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, category: indolines-derivatives

Under nitrogen protection,2 g (0.011 mol) of 7-chloroisatinAnd 2.27 g (0.042 mol) of potassium borohydride were put into a dry four-necked flask,Cooled to -10 ° C or less,Stirring,To this was slowly added dropwise 25 mL of dry tetrahydrofuranAnd 3.5 g (0.025 mol) of borontrifluoride etherate,The whole process control temperature does not exceed -5 ,Reaction overnight,Reaction completed,A solution of 4.5 g of potassium hydrogensulfate and 50 mL of water was slowly added dropwise to the solution,The mixture was distilled by steam,The distillate was extracted with ethyl acetate,Dried over anhydrous magnesium sulfate,The solvent was distilled off,To give 1.18 g of white needles (yield 71.0percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56341-37-8 as follows. Quality Control of 6-Chlorooxindole

EXAMPLE 12a 4-(6-Chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-piperidine-1-carboxylic acid tert-butyl ester A suspension of 6-chlorooxindole (1.68 g, 10 mmol) (Cresent Chem.), 1-BOC-4-piperidone (2.20 g, 11.0 mmol) (Fluka), and piperidine (85 mg, 1 mmol) (Aldrich) in 2-propanol (30 mL) was heated at 100 C. for 2 days. Hot water (30 mL) was added to the hot reaction mixture and mixture allowed to cool to room temperature. After standing in refrigerator for 2 hours, crystalline material was collected and washed with cold aqueous methanol to give 4-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-piperidine-1-carboxylic acid tert-butyl ester as a yellow crystalline material. (Yield 2.88 g, 82.4%). HRMS(ES+) m/z Calcd for C18H21ClN2O3+Na [(M+Na)+]: 371.1133. Found: 371.1135.

According to the analysis of related databases, 56341-37-8, the application of this compound in the production field has become more and more popular.

Electric Literature of 7477-63-6,Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Ethyl 7-(2,3-dioxoindolin-1-yl)heptanoate (2a). A solution of 1a (147mg, 1mmoL) in DMF (3mL) was cooled to ?5°C and K2CO3 (165.5mg, 1.2mmoL) was added. The mixture was stirred for 1h at ?5°C and 45 min at room temperature, then CH3OH (0.5mL) and KI (8.3mg, 0.05 mmoL) were added. After stirring for 15 min, a solution of ethyl 7-bromoheptanoate (237mg, 195muL, 1mmoL) in DMF (1mL) was added and the resulting reaction mixture was stirred at 60°C for 24 h. Upon completion, the reaction mixture was cooled, acidified with 10percent HCl and extracted with DCM (50mL×2). The extracts were pooled and DCM was evaporated under reduced pressure. Compound 2a was obtained as brown?yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Chloroisatin, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 774-47-0, name is 5,6-Difluoroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5,6-Difluoroindoline-2,3-dione

General procedure: In an ordinary vial equipped with a Teflon-coated stir bar, thiourea IV or V (0.04 mmol, 11.89 mg, 20 mol %) was dissolved in 1.0 mL of THF. Then the corresponding isatins 1 (0.1 mmol, 1.0 equiv) was added, followed by the addition of alpha,beta-unsaturated ketones 2 (0.2 mmol, 2.0 equiv). The vial was capped with a rubber stopper and the mixture was stirred at room temperature for the time given in the tables. The crude mixture was then purified by flash column chromatography silica gel, using hexane/ethylacetate 2:1 as the eluent. Solvent was removed in vacuo to give the desired products.

The synthetic route of 774-47-0 has been constantly updated, and we look forward to future research findings.