Tag: M.W=100-200

Synthetic Route of 5428-09-1,Some common heterocyclic compound, 5428-09-1, name is 2-Allylisoindoline-1,3-dione, molecular formula is C11H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To an oven-dried pressure tube were sequentially added aryl carboxylic acid 1 (0.2 mmol), olefin 2 (0.24 mmol), Pd(TFA)2 (3.33 mg, 5.0 molpercent), Ag2CO3 (55.2 mg, 0.2 mmol), THF (2.0 mL) and DMSO (0.10 mL) under nitrogen at room temperature. After degassing three times, the reaction mixture was heated at 100 °C for 8 h, and then was cooled to room temperature. Water (20.0 mL)was added, and the mixture was extracted with ethyl acetate (3 5.0 mL). The combined organic layer was washed with brine, dried over anhydrious Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluant: hexane/ethyl acetate) to give the pure target product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Allylisoindoline-1,3-dione, its application will become more common.

13220-46-7, name is 4-Methylindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Methylindolin-2-one

4-Methyl-oxindole was condensed with 3-(3-hydroxy-propyl)-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole-2-carbaldehyde and piperidine in ethanol to give the title compound. MS (m/z) 351 [M+1].

The synthetic route of 13220-46-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141452-01-9, name is Methyl indoline-5-carboxylate, A new synthetic method of this compound is introduced below., Formula: C10H11NO2

To a solution of methyl indoline-5-carboxylate (200 mg, 1.13 mmol) and acetone (0.17 mL, 2.2 6mmol) in dichloromethane (10 mL) was added acetic acid (0.39 mL, 6.77 mmol). The reaction mixture was stirred at room temperature for 30 minutes before cooling to 0 C in an ice-water bath. Sodium cyanoborohydride (213 mg, 3.39 mmol) was added in 3 portions. The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with dichloromethane (30 mL), washed with saturated solution of NaHCCh (3 x 30 mL) followed by brine (30 mL) and then dried over anhydrous MgS04. Purification by column chromatography (0-70% ethyl acetate in cyclohexane) gave methyl 1 -isopropylindoline-5-carboxylate (45 mg, 0.21 mmol, 18% yield) as a colourless oil. LCMS: MS m/z 220.1 [M+H]+; 1H NMR (400 MHz, DMSO) d 7.64 (dd, J = 8.4, 1.8 Hz, 1H), 7.52 (d, J = 1.5 Hz, 1H), 6.44 (d, J = 8.4 Hz, 1H), 3.96-3.84 (m, 1H), 3.45 (t, J = 8.7 Hz, 2H), 2.93 (t, J = 8.6 Hz, 2H), 1.1 1 (d, J = 6.6 Hz, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 7477-63-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7477-63-6 as follows.

General procedure: A magnetically stirred mixture of naphthalene-1-amine (1.0mmol), isatin (1.0 mmol), dialkyl acetylenedicarboxylate (1.2 mmol) andanhydrous antimony trichloride (0.10 mmol) in dry acetonitrile (3 mL) taken ina 25 mL round bottom flask fitted with a reflux condenser and argon atmosphereand was refluxed for 5h and followed by usual work up and column chromatographyof the crude residue over silica gel (25 percent ethyl acetate in petroleum ether) toafford the pure products (5).

According to the analysis of related databases, 7477-63-6, the application of this compound in the production field has become more and more popular.

Application of 19727-83-4, These common heterocyclic compound, 19727-83-4, name is 6-Nitroindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 2-(6-nitro-2,3-dihydro-1H-indol-1-yl)ethyl methanesulphonate, common to all the examples Step 1: Synthesis of 2-(6-nitro-2,3-dihydro-1H-indol-1-yl)ethanol500 ml of acetonitrile, 50 g (0.304 mol) of 6-nitroindoline, 45.1 ml (1.36 mol) of 2-bromoethanol and 131.5 ml (0.942 mol) of triethylamine are successively charged to a 1 litre three-necked flask equipped with a thermometer, a condenser, a bubbler and a magnetic stirrer, and the mixture is brought to reflux for 24 hours. The reaction medium is then concentrated under vacuum to 1/10 until a red oil is obtained, which is taken up with 600 ml of dichloromethane. The resulting organic phase is washed with 4 x 300 ml of water and dried over sodium sulphate Na2S04. The dichloromethane is eliminated in a rotary evaporator until a dark red solid having a mass of 64.83 g is obtained, which is purified by silica column chromatography (eluent = 90/10 chloroform/methanol) to give 41.13 g (yield 64.8%) of a dark red solid corresponding to the expected product. Analysis by mass spectrometry confirms the structure of the expected compound: the quasi-molecular ions [M+H] + , [M+Na] + , [M+Na+CH3OH]+, [2M+Na]+, [M~H]~ of the expected molecule CioHi2N203 are mainly detected.

Statistics shows that 6-Nitroindoline is playing an increasingly important role. we look forward to future research findings about 19727-83-4.

Reference of 39755-95-8,Some common heterocyclic compound, 39755-95-8, name is 5-Methoxyisatin, molecular formula is C9H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under air conditions,Add pressure tube to each open5-methylisatin (0.5 mmol, 88.5 mg),Cu (OAc) 2 (1.25 mmol, 249.5 mg), and then 2 mL of DMSO was added to the reaction tube. The mixture was stirred in an oil bath at 120 C under magnetic stirring.TLC followed the reaction. Reaction 14h.Cooling stand, the reaction solution was diluted with 5mL CH2Cl2, 30mL water and 2 ~ 3mL ammonia, liquid separation. The aqueous phase was further extracted with CH 2 Cl 2 (3 × 10 mL) and the organic phases were combined,Dry over anhydrous Na2SO4, filter and evaporate the solvent under reduced pressure.Column chromatography EA: PE = 1: 4 yielded 31.3 mg of a yellow solid in 32.8% yield.

The synthetic route of 39755-95-8 has been constantly updated, and we look forward to future research findings.

16800-68-3, name is 1-Acetylindolin-3-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 16800-68-3

General procedure: 1a (35.0 mg, 0.2 mmol, 1 equiv.), tert-BuOK (22.4 mg, 0.2 mmol, 1.0 equiv.) were added to a Schlenk tube. Then 2 ml THF was added using a syringe. The reaction mixture was stirred 15min,and then added iodonium salt 2 (0.2 mmol, 1.0 eq). The reaction was stirred at 30C for 10 hours.After cooling to room temperature, the solvent was removed in vacuo and the residue was purifiedby silica gel using a proper eluent (EtOAc/Hexane) to afford the desired products

The synthetic route of 16800-68-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141452-01-9, name is Methyl indoline-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H11NO2

Under the protection of argon, dissolve bis (trichloromethyl) carbonate (296mg, 1mmol) in 5mL of tetrahydrofuran, cool to 0 C, add triethylamine (202mg, 2mmol), stir for 5 minutes, and add indoline- Methyl 5-carboxylate 3a (177 mg, 1 mmol, prepared according to the published patent application “WO 2010149685”) was reacted at room temperature overnight. 20 mL of 2N dilute hydrochloric acid was added and extracted with dichloromethane (30 mL × 3). The organic phases were combined, washed with a saturated sodium bicarbonate solution (30 mL) and a saturated sodium chloride solution (30 mL), and the organic phase was dried over anhydrous sodium sulfate. , Filtered, and concentrated under reduced pressure to give 1- (chlorocarbonyl) indololine-5-carboxylic acid methyl ester 3b (239 mg, white solid), yield: 100%.

According to the analysis of related databases, 141452-01-9, the application of this compound in the production field has become more and more popular.

Application of 6344-05-4, These common heterocyclic compound, 6344-05-4, name is 4-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the 25 ml dry round-bottom flask is added in 3 ml toluene, 163 mg (1mmol) isatoic anhydride, 181 mg (1mmol) 4- chloroisatin (purchased from Shanghai the nation becomes chemical Company limited), 505 mg (5mmol) triethylamine, then heating to 110 °C, stir at reflux reaction 3-4h, TLC detection display after the reaction is finished, pressure reducing evaporate solvent, residue is recrystallized in ethanol, to obtain the product 7- chlorine tryptamine alkone 225 mg, yield 80percent.

The synthetic route of 6344-05-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50727-04-3, name is 5-Methoxyisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Formula: C9H7NO3

To a suspension of D23 (6.14 g, 35 [MMOL)] in dry tetrahydrofuran (25 mL) was added dropwise BH3-THF (100 mL, 1M in tetrahydrofuran) then heated at reflux overnight. The mixture was cooled to [0C] then quenched by dropwise addition of methanol (10 mL). After stirring at room temperature for 20 minutes 5M HCI (10 [ML)] was added and the mixture heated at reflux for 1 hour. The mixture was cooled to room temperature, the pH adjusted to pH 10 by the addition of 2M [NAOH] (58 mL) and extracted with dichloromethane. The organic layer was dried [(MGS04),] and evaporated. Purification by SCX followed by evaporation gave the title compound D24 as an oil (1.76 g). [MH+] 150.’H NMR [8] (CDCI3) 3.80 (3H, s), 4.17 (2H, s), 4.20 (2H, s), 6.75-6. 83 (2H, m), 7.13 [(1H,] d).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.