Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84378-94-9, HPLC of Formula: C8H3ClFNO2

(b) 7.8 g (0.039 mol) of 4-chloro-5-fluoro-isatin are suspended in 50 ml of 100 percent acetic acid, treated with 0.25 ml of concentrated sulphuric acid and then 4.4 ml (0.043 mol) of 30 percent hydrogen peroxide are added dropwise thereto. The mixture is subsequently heated to 70 for 2.5 hours, then cooled to 10 and filtered. The crude product is recrystallized from acetone/hexane, there being obtained 6-chloro-5-fluoro-isatoic acid anhydride of melting point 275-278 (decomposition).

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Quality Control of 5,7-Dimethylindoline-2,3-dione

General procedure: A magnetically stirred mixture of naphthalene-2-amine (1.0mmol), isatin (1.0 mmol), dialkyl acetylenedicarboxylate (1.2 mmol) andanhydrous antimony trichloride (0.10 mmol) in dry acetonitrile (3 mL) taken in a 10 mL round bottom flask fitted with a reflux condenser under argonatmosphere and was refluxed for 5 h. After completion of the reaction, the reaction mixture was allowed to cool, quenched with water (10 mL) and extracted with DCM (3 x 20 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and volatiles were removed in vacuo. The crude residue was purified by column chromatography over silica gel (100-200mesh), eluting with 25 % ethyl acetate in petroleum ether to afford compound (4).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5428-09-1,Some common heterocyclic compound, 5428-09-1, name is 2-Allylisoindoline-1,3-dione, molecular formula is C11H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Following a slightly modified procedure,3 14 (222 mg, 1.0 mmol, 1.0 equiv) was dissolved in 1 mL of ethylacetate to obtain a 1 M solution. The solution was warmed up to 80 °C with 2-allylisoindoline-1,3-dione(374 mg, 2.0 mmol, 2.0 equiv). After 15 minutes of reflux under nitrogen, DLP (40 mg, 0.1 mmol, 0.1equiv) was added and the solution was stirred 1 hour and monitored by TLC. The crude was concentratedin vacuo and purified by flash column chromatography (PE:EtOAc 80:20 to 70:30) to afford pure 26 (370mg, 0.9 mmol, 90percent) as a light yellow oil and as a mixture of diastereoisomers. Rf (PE:EtOAc 8:2) = 0.12.1H NMR (CDCl3, 400 MHz) delta 7.84-7.80 (m, 2 H, ArH), 7.73?7.69 (m, 2 H, ArH), 4.60-4.49 (m, 2 H,OCH2CH3), 4.27-4.15 (m, 1 H, CHS), 4.03-3.88 (m, 2 H, CH2N), 3.35-3.20 (m, 2 H, CH2S), 2.78-2.64 (m,1.5 H, CH2CH2S, CHCOS), 2.60-2.54 (m, 1 H, CH2CH2S), 2.28-2.18 (m, 1 H, CHCH2CH), 2.05-1.95 (m,0.5 H, CH2CHS), 1.92-1.81 (m, 0.5 H, CH2CH2S), 1.75-1.65 (m, 1 H, CHCH2CH), 1.38 (t, 1.5 H, J = 7.1Hz, OCH2CH3), 1.37 (t, 1.5 H, J = 7.1 Hz, OCH2CH3). 13C NMR (CDCl3, 101 MHz) delta 212.5 (CS2), 212.3(CS2), 209.3 (COS), 209.2 (COS), 168.1 (N(CO)2), 134.2 (ArH), 131.7 (Ar), 123.5 (ArH), 70.6 (OCH2CH3),70.4 (OCH2CH3), 49.5 (CHCOS), 48.3 (CHS), 41.8 (CH2N), 40.3 (CH2N), 32.7 (CH2CH2S), 32.4(CH2CH2S), 32.1 (CHCH2CH), 31.8 (CHCH2CH), 30.3 (CH2CH2S), 30.2 (CH2CH2S), 13.7 (OCH2CH3).COSY, HSQC and HMBC were consistent with this attribution. IR 1773 (NC=O), 1718 (SC=O, NC=O),1223 (SC-O), 1048 (C=S). HRMS (EI) calculated for C18H19NO4S3 [M+] 409.0476; found 409.0481, fragmentationcalculated for C15H14NO3S [M+] 288.0694; found 288.0689.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Allylisoindoline-1,3-dione, its application will become more common.

317-20-4, name is 7-Fluoroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H4FNO2

Is added to the reactor 198 mg (1.2 mmol) 7 – fluoro – isatin and 144.1 mg (1.44 mmol) 2, 4 – pentanedionato, add 50 ml tetrahydrofuran and 5 ml DMF as the reaction solvent, adding 1 ml H2O2And 14.5 mg ZnCl2As the catalyst, the electric jacket is heated to 85 C, magnetic stirring reflux reaction for 12 hours. Thin-layer chromatographic trace to after the reaction is complete, evaporating the solvent under reduced pressure, the filter cake is tetrahydrofuran washing, drying to obtain the target compound 175.5 mg, total yield 59.2%.

The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32372-82-0, name is Isoindoline hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H10ClN

To a solution of isoindoline hydrochloride (1.1, 5.0 g, 32.2 mmol) in DCM (30 ml) was added TFAA (8.1 g, 38.78 mmol) at 0 C. The mixture was allowed to stir at room temperature for 1 h. TLC showed the reaction was complete. The volatiles were evaporated and the residue was partitioned between EtOAc and water. The organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude 2,2,2- trifluoro-1-(isoindolin-2-yl)ethanone (1.2), which was used in next step without further purification. LCMS: 216.2 [M+1]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 32372-82-0.

Related Products of 41910-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41910-64-9, name is 4-Chloroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Initially a 2.5 dram reaction vial was charged with 60% sodium hydride (0.028 g, 0.700 mmol) and salicylamide (0.072 g, 0.525 mmol) in DMF (2 mL).The mixture was allowed to stir at room temperature for 1 hour.4-Chloro-6-ethoxy-2- (pyridin-3-yl) quinazoline (0.100 g, 0.350 mmol) was then added to the mixture and the reaction was allowed to proceed overnight at room temperature.LC-MS analysis of the crude mixture showed that the formed product was about 85% and 10% remained as starting material. Water (30 mL) was added to the mixture and the product was extracted with chloroform (3 × 15 mL). The combined organic layers were dried (Na 2 SO 4), filtered and concentrated. The crude product was purified by ISCO (silica gel, 97.5: 2.5 CH2 Cl2 / MeOH; 12 g column) to afford 13.9 mg of the desired product as a white solid (10.3%).

The synthetic route of 4-Chloroindoline has been constantly updated, and we look forward to future research findings.

Reference of 19155-24-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19155-24-9 as follows.

Step 4: [4-(3,3-Dimethyl-2-oxo-2,3-dihydro-indol-1 -ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester3,3-Dimethyl-1 ,3-dihydro-indol-2-one (commercial) (268 mg, 1.66 mmol) in DMF (10ml_) was treated with NaH (60percent in oil) (80mg, 1.99mmol) and the mixture was stirred at RT for 10 minutes. Trans-trifluoro-methanesulfonic acid 4-tert- butoxycarbonylamino-cyclohexylmethyl ester (600mg, 1.66mmol) was added and the reaction mixture was heated at 80°C for 4 hours. The solvent was removed in vacuo and the residue was partitioned between DCM and water. The organic portion was passed through a phase separator and the solvent was removed in vacuo. Purification by chromatography on silica eluting with iso-hexane/ EtOAc afforded the title compound. 1H NMR (400MHz, d6-DMSO) delta; 7.32 (1 H, m), 7.22 (1 H, m), 7.03 (1 H, m), 3.49 (2H, d), 3.12 (1H, m), 1.73 (2H, m), 1.60 (3H, m), 1.37 (9H, s), 1.23 (6H, s), 1.02 (4H, m).

According to the analysis of related databases, 19155-24-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61-70-1, name is 1-Methylindolin-2-one, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H9NO

General procedure: All reactions were conducted in 10 mL glass vials fitted with crimpcap septum caps. The reaction vial, equipped with a magnetic stir bar,was charged under an N2 atmosphere with 1-methylindolin-2-one (4)(73.6 mg, 0.5 mmol), Pd2(dba)3 (10 mg, 0.011 mmol, 2.5 mol%), i-Pr-BI-DIME (7) (0.022 mmol, 5 mol%), LiHMDS (1 M in toluene, 0.55 mL,0.55 mmol) and the aryl halide (1.1 equiv), then sealed with a crimpcap septum. THF (0.5 mL) and toluene (0.5 mL) were added via syringe and the reaction was heated to 70 C for 4-24 h. The reaction mixture was cooled to room temperature then filtered through a Celite pad with EtOAc (5 mL) as eluent. The filtered solution waswashed with H2O (3 mL), dried over MgSO4 and then concentrated under reduced pressure. The crude residue was purified using a 12 g silica column (30% EtOAc/hexanes) to afford the corresponding oxindole product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 71294-03-6,Some common heterocyclic compound, 71294-03-6, name is 7-Fluoroindolin-2-one, molecular formula is C8H6FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2a-j (1.50 mmol) and 5 (1.50 mmol) in ethanol (10 mL) was treated with a catalytic amount of piperidine. The reaction mixture was stirred under reflux until complete consumption of the substituted indolin-2-ones was observed by TLC. After cooling, the precipitate was filtered, recrystallised from absolute ethanol and dried in air to furnish pure (E)-3-(benzothiazol-2-ylmethylene)indolin-2-ones 6a-j.

The synthetic route of 71294-03-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 16800-68-3,Some common heterocyclic compound, 16800-68-3, name is 1-Acetylindolin-3-one, molecular formula is C10H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1a (35 mg, 0.2 mmol, 1 equiv.), tert-BuOK (22.4 mg, 0.2 mmol, 1.0 equiv.) were added to a Schlenk tube. Then 2 mL THF was added using a syringe. The reaction mixture was stirred 15 min,and then 6 ( 0.2 mmol, 1.0 eq) was added, and the reaction was stirred at room temperature for 10 hours. the solvent was removed in vacuo and the residue was purified by silica gel using a propereluent (EtOAc/Hexane) to afford the desired products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Acetylindolin-3-one, its application will become more common.