Related Products of 32692-19-6,Some common heterocyclic compound, 32692-19-6, name is 5-Nitroindoline, molecular formula is C8H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-nitro-1H-indole (600 mg, 3.0 mmol, 1.0 equiv.), K2CO3 (456 mg, 3.3 mmol,1.1equiv.), (bromomethyl)benzene (615mg, 3.3mmol, 1.1equiv.) dissolved in an appropriate amount of DMF, stirred at 50 C under nitrogenMix overnight. The TLC monitors the reaction in real time. After completion of the reaction, it was diluted with 2N HCl, extracted with three portions of ethyl acetate, and the organic phases were combined.After washing with water, a saturated NaHCO3 solution and a saturated NaCl solution, the organic layer was dried over anhydrous NaSO?Purification by silica gel column gave 1-benzyl-5-nitroindoline (634 mg, yield: 83.2%).
The synthetic route of 32692-19-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fudan University; Wang Yonghui; Yu Fazhi; Li Wei; (38 pag.)CN109232358; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem