Application of 25369-33-9,Some common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: DMF-DMA (2.66 mL, 20.0 mmol) was added to a solution of the appropriate indole (0.78 mmol) in toluene (3 mL). The mixture was stirred for 2-4 h. The precipitate was collected by filtration and washed with dichloromethane.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Chloroindolin-2-one, its application will become more common.
Reference:
Article; Praveen Kumar; Gut, Jiri; Guedes, Rita C.; Rosenthal, Philip J.; Santos, Maria M.M.; Moreira, Rui; European Journal of Medicinal Chemistry; vol. 46; 3; (2011); p. 927 – 933;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem