Synthetic Route of 118289-55-7, These common heterocyclic compound, 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Charged 5- (2-chloroethyl)-6-chloro oxindole (50 GM), 3- (1-PIPERAZINYL)- 1, 2-BENZISOTHIAZOLE (47.5 gm) and cyclohexane (500 mL) into an autoclave. To this sodium carbonate (46 GM), sodium iodide (3.2 GM), tetra butyl phosphonium bromide (14.8 gm) was added and the reaction was maintained at a temperature OF 95-102C and the pressure was kept at 2.5 KG/CM2 TILL the reaction was completed. The reaction mass was cooled to 30C and water (250 mL) was added. The resulting compound was filtered and washed with water (100 mL). The wet compound was further slurred in water (500 mL), filtered and washed with water (100 mL). To the water wet compound was added acetone (500 mL) and was stirred at room temperature for 2 hours and 30 minutes. The solid was filtered, washed with acetone (100 mL) and dried at a TEMPERATURE OF 60-65C to afford the Ziprasidone base (65.7 gm).
The synthetic route of 118289-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DR. REDDY’S LABORATORIES LIMITED; DR. REDDY’S LABORATORIES INC.; WO2004/50655; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem