These common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5,7-Dimethylindoline-2,3-dione
General procedure: A mixture of Yb(OTf)3 (0.01 mmol) and ligand L6 (0.02 mmol) wasstirred at r.t. for 2 h in CH2Cl2 (2 mL). The appropriate enones 1 (1mmol) and isatins 2 (0.1 mmol) were then added. The resulting mixturewas stirred at r.t. After the reaction was completed as monitoredby TLC (eluent: hexane-EtOAc, 1:1), the reaction mixture was purifiedby column chromatography (silica gel, eluent: mixture ofhexane and EtOAc).
The synthetic route of 5,7-Dimethylindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Lu; Daka, Philias; Sarkisian, Ryan; Deng, Yongming; Wheeler, Kraig; Wang, Hong; Synthesis; vol. 46; 10; (2014); p. 1339 – 1347;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem