Related Products of 102359-00-2, These common heterocyclic compound, 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
INTERMEDIATE 8 N-{3-[(4-Fluorophenyl)amino]pyridin-4-yl}-2-oxo-2,3-dihydro-1 H-indole-5- carboxamide2-Oxo-2, 3-dihydro-1 H-indole-5-carboxylic acid (200mg, 1.13mmol), Intermediate 5 (241 mg, 1.19mmol), HATU (644mg, 1.69mmol) and NEt^ (392uL, 2.82mmol) were dissolved in DMF (7.0ml_) and the reaction mixture heated at 60C for 2h. The reaction mixture was concentrated in vacuo, dissolved in EtOAc (50ml_), washed with water (40ml_). Brine (40ml_) was added to the organic phase and the biphasic mixture was filtered to give the title compound (409mg, 100%) as a brown solid. LCMS (ES+): 363.1 [MH]+. HPLC: Rt 4.23min, 79.8% purity.
Statistics shows that 2-Oxoindoline-5-carboxylic Acid is playing an increasingly important role. we look forward to future research findings about 102359-00-2.
Reference:
Patent; PROXIMAGEN LIMITED; PATIENT, Lee; SIMPSON, Iain; SAVORY, Edward; (51 pag.)WO2016/42332; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem