In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(3-Oxobutyl)isoindoline-1,3-dione
A solution of 4-(3-piperidin-4-yl-3-thiophen-3-ylmethyl-ureidomethyl)-benzoic acid methyl ester (97 mg, 0.25 mmol), 2-(3-oxo-butyl)-isoindole-l,3-dione (109 mg, 0.50 mmol) and glacial AcOH (5 drops) in MeOH (1.2 ml) at 60 C was added NaBH3CN (50 mg, 0.80 mmol) and the reaction was stirred for 20.5 hours. The reaction was cooled, diluted with saturated aqueous NaHCO3 (25 ml) and was extracted with CH2Cl2 (20 ml X 3). The combined organic solution was dried (Na2SO4), filtered and concentrated under reduced pressure. Purification by flash column chromatography on silica (CH2Cl2/MeOH, 29:1) gave the tertiary piperidine as a white foam (86.3 mg, 59%). 1H NMR (CDCl3) delta 0.95 (d, 3H, J= 6.2 Hz), 1.18-1.71 (m, 5H), 1.84-1.97 (m, IH), 2.09-2.20 (m, IH), 2.40-2.50 (m, IH), 2.63-2.83 (m, 3H), 2.64-2.88 (m, 2H), 3.89 (s, 3H), 4.11 (s, 2H), 4.19-4.31 (m, IH), 4.36 (d, 2H, J= 5.3 Hz), 4.69 (t, IH, J= 5.3 Hz), 6.92 (d, IH, J= 5.1 Hz), 7.04 (s, IH), 7.09 (d, 2H, J= 8.4 Hz), 7.33 (dd, IH, J= 5.1, 3.1 Hz), 7.57-7.63 (m, 2H), 7.75-7.81 (m, 2H), 7.90 (d, 2H, J= 8.4 Hz).
The synthetic route of 3783-77-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem