Related Products of 118289-55-7, A common heterocyclic compound, 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, molecular formula is C10H9Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 37 5-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethyl)-6-chloroindolin-2-one The product of Reference Example 31 (120 mg, 0.553 mmol), 6-chloro-5-(2-chloroethyl)indolin-2-one (150 mg, 0.663 mmol), potassium carbonate (230 mg, 1.66 mmol), potassium iodide (90 mg, 0.553 mmol) and water (5 ml) were added to the flask. The mixture was stirred at 105 C. for 12 hours, cooled, filtered. The filter cake was slurried in acetonitrile and filtered to give the product (155 mg, yield: 58%). 1H-NMR (400 Hz, DMSO-d6): delta ppm 10.43 (s, 1H), 7.84 (d, 1H), 7.76 (d, 1H), 7.62 (d, 1H), 7.33 (t, 1H), 7.26 (d, 1H), 7.23 (s, 1H), 6.81 (s, 1H), 3.47 (s, 2H), 3.08 (d, 3H), 2.84 (t, 2H), 2.51 (m, 2H), 2.23 (t, 2H), 1.79 (m, 4H). ESI-MS (m/z): 411.3 [M+H]+.
The synthetic route of 118289-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem