Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Formula: C8H4BrNO2
To a solution of 4a (10 g, 44.4 mmol) in TRF (200 mE) was added NaI3R4 (17.6 g, 464.8 mmol), followed by 13F3.Et20 (170 ml, 519.2 mmol) drop- wise at room temperature. The mixture was then heated at 80 C. overnight, cooled to 0 C. and adjusted to pH 13 with aqueous NaOH solution. The mixture was extracted with ethyl acetate (100 mEx3). The combined organic phase was washed with water, brine and dried over anhydrous Na2504. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (DCM:MeOR=10:1, v: v) to provide 4b (7.3 g, 83% yield). EC-MS: 198 [M+1].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; HELSINN HEALTHCARE SA; Giuliano, Claudio; Daina, Antoine; Pietra, Claudio; (254 pag.)US2017/275301; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem