Application of 1074-82-4,Some common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, molecular formula is C8H4KNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-(4-Aminophenyl)morpholin-3-one (100 gm) was added in n-butanol (300 ml) and charged Alumia sulfonic acid at ambient temperature. Cool the mass, added (R)-Epichlorohydrin (72 gm) and maintain the reaction mass at below 20C. Confirmed the completion of reaction, separated the catalyst. Added sodiumbicarbonate, cool the mass temperature to Q-5C and added methylchloroformate (56 gm) . After completion of reaction, evaporated the n- butanol and charged N,N-dimethylformamide (500 mi), potassium phthalimide (122 gm). The reaction temperature maintained at 95- 100C for 3 hours. Cool the mass temperature to ambient temperature, quenched the mass into water. Filtered the mass and washed the product with water. Dried the material up to get constant weight. The obtained 2-({(5Sj-2-Qxo-3-[4-(3-Gxo-4- morpholmyl]phenyl ]– 1 ,3–oxazol.idm-5–yl}methyl)– 1 H–isoindole– 1 ,3(2H)–d.ione was 186 gm (85% yield) .
The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHALANX LABS PRIVATE LIMITED; AVIRNENI, Srirama Krishna; TADIMALLA, Venkata Srihari; GOTTIMUKKULA, Venkata Mallaparaju; MOTAMARRI, N.V. Suryanarayana Murthy; KOTICHUKKALA, Yesubabu; M.S.S., Prakash; SABBAVARAPU, Suribabu; (18 pag.)WO2018/55499; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem