Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H9NO3
Add 420 ml of dioxane to the flask, 33.0 g of compound 2, 25.6 gN-hydroxyethyl phthalimideAnd 55.0g sodium hydroxide,An additional 5.5 g of PEG-400 was added. The temperature was raised to reflux for 3 h, cooled to room temperature and filtered.The filtrate was concentrated under reduced pressure to nearDry, add 300ml water and stir for 1h, can not be cured.Extracted with toluene (50 ml x 3), combined with toluene, washed with water and dried.The solvent was evaporated to give a pale brown viscous liquid.Yield: 89.1%, purity: 92.5% (according to high-performance liquid chromatography peak area normalization method)meter).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Changzhou Ruiming Pharmaceutical Co., Ltd.; Shi Weiming; Zhou He; Wang Xiaoliang; (6 pag.)CN107935912; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem