Synthetic Route of 20780-72-7, A common heterocyclic compound, 20780-72-7, name is 4-Bromoisatin, molecular formula is C8H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(3) 10 mL DMF dissolution step (2) The obtained compound 4.4 mmol, 1.8 g of potassium carbonate, 1.1 g of 4-chlorobenzyl bromide, and stirred under argon atmosphere for 2 hours at room temperature; TLC analysis determined that after the reaction was completed, The reaction was quenched by the addition of excess ice water and stirred for 30 minutes; Filter the suspension and dry the filter cake. Obtained as a red solid (Compound 4b 1.34 g, yield 90percent, without further purification);
The synthetic route of 20780-72-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin University of Science and Technology; Diao Aipo; Li Yuyin; Yu Peng; Liu Yang; Li Zhipeng; (15 pag.)CN109574907; (2019); A;,
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