1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-(3-Oxocyclopentyl)isoindoline-1,3-dione
Example 58B 2-(3-hydroxy-3-phenylcyclopentyl)isoindoline-1,3-dione A solution of Example 58A (1.00 g, 4.36 mmol) and THF (20 mL) was cooled to <-70 C. and phenylmagnesium chloride (2.40 mL, 4.80 mmol) was added at <-70 C. After 2 hours, saturated aqueous NH4Cl (20 mL) was added and the mixture was extracted with MTBE (50 mL). The organic layer was dried (Na2SO4) and concentrated. The residue was puridifed by flash column chromatography (0-20% EtOAc/hexanes, gradient elution), to provide the title compound (370 mg, 1.20 mmol, 27.6% yield).
The synthetic route of 1029691-06-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; US2012/245163; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem