Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, A new synthetic method of this compound is introduced below., Product Details of 118289-55-7
Example 42 6-chloro-5-(2-(4-(thieno[2,3-c]pyridin-4-yl)piperazin-1-yl)ethyl)indolin-2-one The product of Reference Example 26 (200 mg, 0.632 mmol), 6-chloro-5-(2-chloroethyl)indolin-2-one (160 mg, 0.695 mmol), potassium carbonate (218 mg, 1.58 mmol), potassium iodide (157 mg, 0.948 mmol) were added to acetonitrile (7.5 ml) and the mixture was stirred at 80 C. overnight. The reaction mixture was concentrated and subjected to column chromatography to obtain a white solid (25 mg, yield: 8.7%). 1H-NMR (300 Hz, DMSO-d6): delta ppm 10.41 (s, 1H), 8.89 (s, 1H), 8.04 (m, 2H), 7.51 (d, 1H), 7.23 (s, 1H), 6.81 (s, 1H), 3.46 (s, 2H), 3.18 (brs, 4H), 2.85 (t, 2H), 2.71 (brs, 4H), 2.56 (t, 2H). ESI-MS (m/z): 413.3 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem