Application of 19727-83-4, These common heterocyclic compound, 19727-83-4, name is 6-Nitroindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of 2-(6-nitro-2,3-dihydro-1H-indol-1-yl)ethyl methanesulphonate, common to all the examples Step 1: Synthesis of 2-(6-nitro-2,3-dihydro-1H-indol-1-yl)ethanol500 ml of acetonitrile, 50 g (0.304 mol) of 6-nitroindoline, 45.1 ml (1.36 mol) of 2-bromoethanol and 131.5 ml (0.942 mol) of triethylamine are successively charged to a 1 litre three-necked flask equipped with a thermometer, a condenser, a bubbler and a magnetic stirrer, and the mixture is brought to reflux for 24 hours. The reaction medium is then concentrated under vacuum to 1/10 until a red oil is obtained, which is taken up with 600 ml of dichloromethane. The resulting organic phase is washed with 4 x 300 ml of water and dried over sodium sulphate Na2S04. The dichloromethane is eliminated in a rotary evaporator until a dark red solid having a mass of 64.83 g is obtained, which is purified by silica column chromatography (eluent = 90/10 chloroform/methanol) to give 41.13 g (yield 64.8%) of a dark red solid corresponding to the expected product. Analysis by mass spectrometry confirms the structure of the expected compound: the quasi-molecular ions [M+H] + , [M+Na] + , [M+Na+CH3OH]+, [2M+Na]+, [M~H]~ of the expected molecule CioHi2N203 are mainly detected.
Statistics shows that 6-Nitroindoline is playing an increasingly important role. we look forward to future research findings about 19727-83-4.