Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Trifluoromethoxy)indoline-2,3-dione
General procedure: N-(4-Sulfamoylphenyl)hydrazinecarbothioamide (2) (3.5mmol) was added to a solution of 1H-indole-2,3-diones 3a-m (3.5mmol) in ethanol (20mL). After addition of a drop of concentrated sulfuric acid, the mixture was refluxed on a water bath for 4h. The product formed after cooling was filtered and washed with ethanol or recrystallized from ethanol.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.