These common heterocyclic compound, 6872-06-6, name is 2-Methylindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Methylindoline
General procedure: Concentrated H2SO4(1.16 mmol in the case of amine 2a or 0.65 mmol in thecase of amines 2b,c,e,f) was added to a mixture of amine2a-,e,f (1.55 mmol) and 2 (20 ml). The mixture wasstirred at 60-70 until complete dissolution of amine.6-Chloropurine (1a) (200 mg, 1.29 mmol) was then added,and the obtained mixture was refluxed for 6 h, cooled, andtreated with aqueous ammonia to 8-9 with stirring. Theprecipitate that formed was filtered off and washed withcold water (3×3 ml). Compound 3a did not need furtherpurification, compounds 3b,c,e,f were purified by silica gelflash chromatography (eluent 95:5 CHCl3-MeOH).
The synthetic route of 2-Methylindoline has been constantly updated, and we look forward to future research findings.