Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, Application In Synthesis of Isoindoline
A mixture of 31 -1 (100 mg, 0.306 mmol), isoindoline (47 mg, 0.398 mmol) and HATU (232 mg, 0.611 mmol) in THF (10 mL) was stirred for 10 min at room temperature. DIPEA (99 mg, 0.764 mmol) was added and the reaction mixture was stirred overnight. The volatiles were evaporated and the resulting residue was partitioned between ethyl acetate (10 mL) and water (10 mL). The organic layer was separated and washed with brine (3 X 10 mL), dried over Na2SO4 and concentrated under vacuum. The resulting residue was purified on silica gel column chromatography eluting with dichloromethane/methanol (100: 1) to afford 31 -2 (180 mg, 70%) as a white solid. LRMS: calc 428.2 and found: 429.1 [M+l].General conditions for step 1: amine, BOP, TEA in DMF .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.