Month: April 2021

Reference of 161596-47-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a article, author is Huang, Jiann-Jyh, introduce new discover of the category.

In this study, we reported the inhibition profiles of 4 ‘-acylpyrrole-5-fluoroindolin-2-one 3 with a C-3 ‘ side chain for VEGFR2, PDGFR-beta, and FGFR-1 protein kinases. The pyrrole-fused cyclohexanone moiety provided 3 with the best potency to inhibit the three kinases, and the C-3 ‘ side chains contributed to the different inhibition profiles of 3. Compound 3b with a C-3 ‘ 2-carboxylethyl side chain showed good potency for the three kinase (IC50: 25-260 nM), and compound 3g with a N,N-dialkyl-2-carbamoylethyl side chain was more active for VEGFR2 (IC50: 59 nM) and PDGFR-beta (IC50: 16 nM) than FGFR-1 (IC50: 1.7 mu M). The C-3 ‘ 3-(dialkylamino)propyl side chain accomplished 3h-j as selective PDGFR-beta inhibitors (IC50: 7.8-13 nM). Compound 3b was further investigated and found potent to inhibit VEGF- and FGF-dependent cell proliferation with moderate in vivo anticancer activity. Results from docking simulations revealed that the interactions of 3b with VEGFR2 and FGFR-1 which could account for the different inhibition profiles of 3.

Reference of 161596-47-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 161596-47-0.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Application of 88150-75-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 88150-75-8, Name is Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate, SMILES is O=C(OCC)CC(COCCN(C(C1=C2C=CC=C1)=O)C2=O)=O, belongs to indolines-derivatives compound. In a article, author is Yamaguchi, Ayuta, introduce new discover of the category.

Heterocycle-fused indoles or indolines are distributed widely in a variety of natural products, bioactive agents, and pharmaceuticals. Herein, we describe the development of gold catalyzed cascade reactions of anilines with diynes to form eight-membered ring-fused indoles and propellane-type indolines, both of which proceed through an intramolecular 5-endo-dig hydroamination followed by an 8-endo-dig cycloisomerization. Controllable formation of eight-membered ring-fused indoles and propellane-type indolines was achieved through selection of the ligands and/or solvents. Protic solvents such as alcohols or IPr ligand favored the formation of eight-membered ring-fused indoles, whereas the use of Buchwald’s type ligands and/or nonpolar solvents gave propellane-type indoline predominantly. This reaction provides rapid access to two types of fused nitrogen heterocycles from simple aniline derivatives.

Application of 88150-75-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 88150-75-8 is helpful to your research.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 550-44-7, Name is 2-Methylisoindoline-1,3-dione, SMILES is CN1C(=O)C2=C(C=CC=C2)C1=O, belongs to indolines-derivatives compound. In a document, author is Nikolaeva, O. G., introduce the new discover, Product Details of 550-44-7.

Indoline spiropyrans containing benzo[f]coumarin moiety annulated to the 2H-pyran cycle were synthesized. The obtained compounds exist in solutions as a tautomeric mixture of their spirocyclic and merocyanine forms. The spiro form exhibits an enhanced resistance to UV irradiation and does not rearranges into the merocyanine isomer in the temperature range of 278-303 K.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 550-44-7 is helpful to your research. Product Details of 550-44-7.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 550-44-7, Name is 2-Methylisoindoline-1,3-dione, SMILES is CN1C(=O)C2=C(C=CC=C2)C1=O, belongs to indolines-derivatives compound. In a document, author is Shi, Yang, introduce the new discover, Application In Synthesis of 2-Methylisoindoline-1,3-dione.

1,3-Dipolar cycloaddition of isatin N,N ‘-cyclic azomethine imine catalyzed by CuCO3 has been developed. Structurally interesting heterocyclic spiro(indoline-3,1 ‘-pyrazolo[1,2-a]pyrazoles) have been synthesized as single regioisomers in good yields and high functional group compatibility.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 550-44-7 is helpful to your research. Application In Synthesis of 2-Methylisoindoline-1,3-dione.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Synthetic Route of 99365-40-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 99365-40-9, Name is 6-Bromoindolin-2-one, SMILES is O=C1NC2=C(C=CC(Br)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Gobinath, Perumal, introduce new discover of the category.

In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1H-spiro [acridine-9,2 ‘-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, H-1-NMR, C-13-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound 1c was more effective (GI(50) 0.01 mu m) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.

Synthetic Route of 99365-40-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 99365-40-9.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 550-44-7, Name is 2-Methylisoindoline-1,3-dione, formurla is C9H7NO2. In a document, author is Sallam, Hanan A., introducing its new discovery. Application In Synthesis of 2-Methylisoindoline-1,3-dione.

The high functionality compound namely 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl chloride (1) was utilized as a building block synthon via reactions with some nitrogen and sulfur nucleophilic reagents. The present work was planned to study the effect of 2-cyano group on the reactivity and stability of C-2-C-3 double bond toward different strong-to-weak nucleophiles, in addition to its facility of nucleophilic addition at C-2-C-3 double bond to construct new heterocyclic derivatives. The proclivity toward some mono-, 1,2-, 1,3-, 1,4-, and 1,5-binucleophiles was investigated. The reaction with 2-cyanoacetohydrazide was mainly dependent on the reaction conditions. Some new heterocycles integrated with pyrazole scaffold were successfully synthesized, such as benzoxazinone, indoline, isoindoline, pyrazolone, chromene, and pyrimidopyrimidine derivatives. Some of the newly synthesized compounds were screened for their antioxidant activity using ABTS method, and the results revealed that some compounds exhibited promising inhibitory antioxidant activity.

If you are hungry for even more, make sure to check my other article about 550-44-7, Application In Synthesis of 2-Methylisoindoline-1,3-dione.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Electric Literature of 56341-37-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 56341-37-8, Name is 6-Chlorooxindole, SMILES is O=C1NC2=C(C=CC(Cl)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Subramanian, Santhosh, introduce new discover of the category.

Microtubules play a dynamic role during cell division. In our early studies 4-phenyl-1-(1-acylindoline-5-sulfonylimidazolones were thoroughly explored and found that the indoline bicyclic system next to the sulfonyl group is very important for cytotoxicity. In this research, imidazolone motif was replaced with pyrrolidin-2-one and this isosteric replacement led to show some promising activity. Thus, the structure activity relationship of 4-phenyl-1-(1-acylindolin-5-ylsulfonyl)pyrrolidin-2-ones with the various acyl group at the indoline NH was explored. The presence of benzoyl groups with electron donating group was the more favorable for cytotoxicity while less bulky alkanoyl groups led to decrease cytotoxicity.

Electric Literature of 56341-37-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56341-37-8 is helpful to your research.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 56341-37-8, Name is 6-Chlorooxindole, formurla is C8H6ClNO. In a document, author is Zhou, Hai-Shan, introducing its new discovery. Recommanded Product: 6-Chlorooxindole.

The Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2)-ARE (antioxidant response element) pathway is the major defending mechanism against oxidative stresses, and directly disrupting the Keap1-Nrf2 protein-protein interaction (PPI) has been an attractive strategy to target oxidative stress-related diseases, including cardiovascular diseases. Here, we describe the design, synthesis, and structure-activity relationships (SARs) of indoline-based compounds as potent Keap1-Nrf2 PPI inhibitors. Comprehensive SAR analysis and thermodynamics-guided optimization identified 19a as the most potent inhibitor in this series, with an IC50 of 22 nM in a competitive fluorescence polarization assay. Further evaluation indicated the proper drug-like properties of 19a. Compound 19a dose-dependently upregulated genes and protein level of Nrf2 as well as its downstream markers and showed protective effects against lipopolysaccharide-induced injury in both H9c2 cardiac cells and mouse models. Collectively, we reported here a novel indoline-based Keap1-Nrf2 PPI inhibitor as a potential cardioprotective agent.

If you are hungry for even more, make sure to check my other article about 56341-37-8, Recommanded Product: 6-Chlorooxindole.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

550-44-7, Name is 2-Methylisoindoline-1,3-dione, molecular formula is C9H7NO2, belongs to indolines-derivatives compound, is a common compound. In a patnet, author is Glinka, Adam, once mentioned the new application about 550-44-7, SDS of cas: 550-44-7.

The photovoltaic performance of solar cells sensitized with indoline D205 dye and its new derivative comprising an alkoxysilyl anchoring unit (D205Si) in the [Cu(tmby)(2)](TFSI)(2/1) (tmby = 4,4′,6,6′-tetramethyl-2,2′-bipyridine, TFSI = bis(trifluoromethane)sulfonimide) redox couple mediated systems was studied in the presence of various titania/dye/electrolyte interface modifications. Cucurbit[7]uril (CB7) was employed to encapsulate dye molecules, creating an electronically insulating layer, suppressing electron interception by redox mediator, and leading to the increase in the electron lifetime in the titania conduction band. For example, the electron lifetime increased from 2.2 to 6.5 ms upon CB7 encapsulation of D205 cells at 0.9 V voltage. Further, molecular multicapping was optimized to minimize dye desorption and prevent electron recombination. As a result, photovoltaic performance was found to be enhanced by the interface modifications in most cases, especially when applied to the alkoxysilyl anchoring derivative. The charge transfer processes (dye regeneration, titania-dye and titania-redox mediator recombination) in the above-mentioned system and in the reference [Co(bpy)(3)](TFSI)(3/2) (bpy = 2,2′-bipyridine) redox couple mediated systems were investigated by means of small light perturbation electron lifetime measurements, electrochemical impedance spectroscopy, and nanosecond and femtosecond transient absorption spectroscopies. Indoline dyes were also found to be outstandingly fast regenerated by the Cu-based mediator (time constant shorter than 100 ns), which may open new opportunities for sensitizer improvements.

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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 59-48-3, Name is Indolin-2-one, molecular formula is , belongs to indolines-derivatives compound. In a document, author is Filatov, Vadim, Recommanded Product: 59-48-3.

A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3 ‘-indoline]-2 ‘,4-diones was developed based on Staudinger ketene-imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and an organic base. A series of [azetidine-2,3 ‘-indoline]-2 ‘,4-diones were synthesized using this method. For comparison, the same compounds were obtained using a known technique, where ketene is generated from pre-synthesized acyl chloride. It was shown that the use of oxalyl chloride for ketene generation in the one-pot reaction at room temperature allows for the reversal of the diastereoselectivity of spiro-lactam formation, unlike previously described procedures.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59-48-3, in my other articles. Recommanded Product: 59-48-3.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem