Month: April 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Quality Control of 2-(4-Bromobutyl)isoindoline-1,3-dione

A 1.0 g portion of JV-[4- (bromo)butyl]phthalimide 21 (0.0035 mol) was dissolved in 10 mL of DMF, and to this solution was added 0.290 g (0.0044 mol) of sodium azide. The reaction was then allowed to stir for 5 h under nitrogen, after which the reaction mixture was concentrated in vacuo to yield a white semisolid. The semisolid was dissolved in water and extracted with three 50 mL portions of ethyl acetate, the combined organic layers were dried over anhydrous magnesium sulfate and filtered, and the solvent was removed to afford 22 (0.760 g, 88%) as a white amorphous powder. This preparation was used in the next reaction without further purification. 1H NMR (400 MHz CDCl3) delta 1.6-1.68 (m, 2H), 1.74-1.82 (m, 2H), 3.3 (t, J= 7.2 Hz, 2H), 3.7 (t, J= 7.2 Hz5 2H), 7.71-7.73 (m, 2H), 7.83-7.86 (m, 2H). 13C NMR(400 MHz CDCl3) delta 26.1, 28.6, 44.02, 53.6, 127.4, 128.0, 132.34, 134.12, 168.52, 171.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

480-91-1, name is Isoindolin-1-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 480-91-1

To a suspension of sodium hydride freshly-washed with hexane (450 mg, 11.26 mmol) in freshly-distille THF (25 mL) was slowly added a solution of isoindolin-1-one (1.00 g, 7.51 mmol) in THF (25 mL) under an N2 atmosphere at 0C and stirred for 30 min. To the resulting reaction mixture was added tert-butyl bromoacetate (1.66 mL, 11.26 mmol) and stirring was continued at room temperature (16 h). The reaction mixture was carefully quenched with methanol and concentrated to obtain a crude residue. The crude product was then further purified by column chromatography (hexanes/ethyl acetate, 4:1) to afford pure isoindolinone ester 2 as an off-white solid (1.80 g, 97%); mp = 62-64C; Rf = 0.33 (hexane/ethyl acetate, 2:1); FT-IR (neat) 2972, 2932, 1738, 1687 cm -1; 1H NMR (400 MHz, CDCl3) delta 7.87-7.85 (d, J = 7.6 Hz, 1H), 7.54-7.52 (m, 1H), 7.47-7.43 (m, 2H), 4.51 (s, 2H), 4.29 (s, 2H), 1.46 (s, 9H) ppm. 13C NMR (100 MHz, CDCl3) delta 168.8, 168.1, 141.6, 131.9, 131.6, 127.9, 123.9, 122.7, 82.2, 50.5, 44.5, 28.1 ppm. LRMS calcd for C14H17NO3 (M+H) 248, found 248.

The synthetic route of 480-91-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 6341-92-0, name is 6-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6341-92-0, Quality Control of 6-Chloroisatin

General procedure: Substituted isatin (10 mmol) was dissolved in hydrazine hydrate (98%, 10 mL, 32.5 mmol) and refluxed for 15-30 min (130 C). The reaction mixture was then poured into cold water, extracted withethyl acetate. The organic layer was then dried over sodium sulfate. Evaporation of the solvent and recrystallization from hexane/ethylacetate provided the substituted oxindole.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloroisatin, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20780-72-7, name is 4-Bromoisatin, A new synthetic method of this compound is introduced below., Formula: C8H4BrNO2

General procedure: 4-Bromoisatin (1 eq) was added to a solution of the potassium trifluoroborate salt (1.4 eq), K3P04 (3.6 eq) and degassed solvent. The reaction mixture was degassed and Pd(PPh3)2C12or Pd(dppf)2C12 (0.1 eq) was added. The reaction vessel was sealed and heated by microwave irradiation (Biotage Initiator) for 4 h at 130°C. The reaction mixture was cooled to rt, diluted with EtOAc (-10 mL/mmol substrate) and filtered through Celite®. The organic solution was washed with brine (-10 mL/mmol substrate) and the resulting aqueous layer was further extracted with EtOAc (2 x). The combined organic layers were dried over MgSO4, filtered andconcentrated in vacuo to give the crude product which was purified as specified below.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 99365-40-9,Some common heterocyclic compound, 99365-40-9, name is 6-Bromoindolin-2-one, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6-Brornoindohn-2-one 27) (2 00 u, 9 40 mmol) bispmacolatodiboron (6 00 g 23 60 mniol), potassium acetate (2.76g. 28.2 mmol) and diehloro[i,i?bis(dipheuylphosphino)feuocenrJj palladrum (11) dichloromethane addutt (0 40 g 0 55 rnniol) in DM80 (30 niL) were stirred at 90 C tbr 18 hours, The reaction mixture was cooled to ambient temperature., then partitioned between water and ethyl acetate. Thelayers were separated and the aqueous layer extracted again with ethyl acetate (2x). The combined organic layers were washed with water and brine and concentrated to give a purple solid. The crude material was pre-absorbed onto Celite and chroniatographed (?DCVC) eluting with a gradient of ethyl acetate in heptane (0 50% ethyl. acetate.) Like fractions were combined and recrystallised from DCM and PE to give 6-(4,5,5-tetrainethyi-l,3,2-dioxahorolan-2yi)indoiin-2-one (24) as a colourless solid in 2 crops (1.33 g, 55%); nip 178.5 181.4 C. ?H NMR (200 MHz, CDCI3) 8 8.61 (br s, 1H), 7.46 (d, 111. J7,4 Hz), 7.30 (s, lH), 7.21 (d. lH,J7.4 Hz), 3.53 (s, 2H). 1.32 (s. 1211).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromoindolin-2-one, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 774-47-0, name is 5,6-Difluoroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5,6-Difluoroindoline-2,3-dione

General procedure: In an ordinary vial equipped with a Teflon-coated stir bar, thiourea IV or V (0.04 mmol, 11.89 mg, 20 mol %) was dissolved in 1.0 mL of THF. Then the corresponding isatins 1 (0.1 mmol, 1.0 equiv) was added, followed by the addition of alpha,beta-unsaturated ketones 2 (0.2 mmol, 2.0 equiv). The vial was capped with a rubber stopper and the mixture was stirred at room temperature for the time given in the tables. The crude mixture was then purified by flash column chromatography silica gel, using hexane/ethylacetate 2:1 as the eluent. Solvent was removed in vacuo to give the desired products.

The synthetic route of 774-47-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 7477-63-6,Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Ethyl 7-(2,3-dioxoindolin-1-yl)heptanoate (2a). A solution of 1a (147mg, 1mmoL) in DMF (3mL) was cooled to ?5°C and K2CO3 (165.5mg, 1.2mmoL) was added. The mixture was stirred for 1h at ?5°C and 45 min at room temperature, then CH3OH (0.5mL) and KI (8.3mg, 0.05 mmoL) were added. After stirring for 15 min, a solution of ethyl 7-bromoheptanoate (237mg, 195muL, 1mmoL) in DMF (1mL) was added and the resulting reaction mixture was stirred at 60°C for 24 h. Upon completion, the reaction mixture was cooled, acidified with 10percent HCl and extracted with DCM (50mL×2). The extracts were pooled and DCM was evaporated under reduced pressure. Compound 2a was obtained as brown?yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Chloroisatin, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56341-37-8 as follows. Quality Control of 6-Chlorooxindole

EXAMPLE 12a 4-(6-Chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-piperidine-1-carboxylic acid tert-butyl ester A suspension of 6-chlorooxindole (1.68 g, 10 mmol) (Cresent Chem.), 1-BOC-4-piperidone (2.20 g, 11.0 mmol) (Fluka), and piperidine (85 mg, 1 mmol) (Aldrich) in 2-propanol (30 mL) was heated at 100 C. for 2 days. Hot water (30 mL) was added to the hot reaction mixture and mixture allowed to cool to room temperature. After standing in refrigerator for 2 hours, crystalline material was collected and washed with cold aqueous methanol to give 4-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidene)-piperidine-1-carboxylic acid tert-butyl ester as a yellow crystalline material. (Yield 2.88 g, 82.4%). HRMS(ES+) m/z Calcd for C18H21ClN2O3+Na [(M+Na)+]: 371.1133. Found: 371.1135.

According to the analysis of related databases, 56341-37-8, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 18711-13-2, name is 4,7-Dichloroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18711-13-2, Formula: C8H3Cl2NO2

4,7-Dichloro-3-(2-(4-cyclopropyl-3-fluorophenyl)-2-oxoethyl)-3-hydroxyindolin-2- one (EXAMPLE 17): To 4,7-dichloroindoline-2,3-dione (A) (261 mg, 1.21 mmol) in 15 mL of methanol were l-(4-cyclopropyl-3-fluorophenyl)ethanone (B) (280 mg, 1.57 mmol) and 10 drops of diethylamine (2). The reaction was stirred at 50C for 24 hours. The solvent was removed and the residue was purified with flash chromatography (0-5% Methanol/CH2C12) to get an off white solid. 4,7-Dichloro-3-(2-(4-cyclopropyl-3-fluorophenyl)-2-oxoethyl)-3- hydroxyindolin-2-one (EXAMPLE 17): off-white solid; 1H NMR (DMSO-d6, 400 MHz) delta 0.83 (m, 2H), 1.08 (m, 2H), 2.1 l(m, 1H), 3.68 (d, 1H, J=16 Hz), 4.34 (d, 1H, J=16Hz), 6.43(s, 1H), 6.90(d, 1H, J=8Hz), 7.11 (m, 1H), 7.30 (d, 1H, J=8Hz), 7.60(d, 1H, J=8Hz),7.68 (d, 1H, J=8Hz), 10.96 (s, 1H). Chiral separation was performed by a method substantially similar to the method described above. LC screening was performed with: column: AD-H, 250 mm x 4.6 mm, 5 mum, hexane/ethanol (65/35), 1.5 ml/min, injection volume: 10.0 mu, pressure: 102.9 bar. Peak 1 : retention time: 5.40 min, width: 0.171 min, area: 4502.21, area %: 50.08. Peak 2: retention time: 7.23 min, width: 0.239 min, area: 4488.43, area %: 49.92.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,7-Dichloroindoline-2,3-dione, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, category: indolines-derivatives

Under nitrogen protection,2 g (0.011 mol) of 7-chloroisatinAnd 2.27 g (0.042 mol) of potassium borohydride were put into a dry four-necked flask,Cooled to -10 ° C or less,Stirring,To this was slowly added dropwise 25 mL of dry tetrahydrofuranAnd 3.5 g (0.025 mol) of borontrifluoride etherate,The whole process control temperature does not exceed -5 ,Reaction overnight,Reaction completed,A solution of 4.5 g of potassium hydrogensulfate and 50 mL of water was slowly added dropwise to the solution,The mixture was distilled by steam,The distillate was extracted with ethyl acetate,Dried over anhydrous magnesium sulfate,The solvent was distilled off,To give 1.18 g of white needles (yield 71.0percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.