5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 5332-26-3
By preheating the internal reactor is sufficiently dried, after substituting dry nitrogen, into the reactor, 4-[ (2-methacryloyloxy) halogenoethoxy]-4-aminobutyric oxopiperidine 11. 51g (0. 05mol), triethylamineborane 6. 07g (0. 06mol), dimethyl formamide (DMF) 150 ml is added. By heating the oil bath 65 C, while stirring, N-(bromomethylbiphenyl) tetrafluorophthalimide 12. 00g (0. 05mol) dissolved in 15 minutes to DMF100mL is added. After the first period, by distilling evaporator DMF, residue extracted with ethyl acetate is obtained. The extract is washed with water to 3 times, then the saturated aqueous solution of sodium bicarbonate, saturated saline successively washed, dried with sodium sulfate (desiccant). Furthermore, after the drying agent is then filtered by a Buchner funnel, distilling organic solvent. In this way, the eq. (M-20) shown (1, 3-dioxo isoindolin-2-yl) methyl 2-(methacryloyloxy) ethyl succinate (13. 95g (yield 72%))is obtained.
The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JSR CORPORATION; ASANO, YUSUKE; SATO, MITSUO; (60 pag.)JP2015/38072; (2015); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem