New downstream synthetic route of 3783-77-5

Adding a certain compound to certain chemical reactions, such as: 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3783-77-5, SDS of cas: 3783-77-5

Adding a certain compound to certain chemical reactions, such as: 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3783-77-5, SDS of cas: 3783-77-5

b. 1-Bromo-4-phthalimidobutan-2-one (10a) To a suspension of 130 g (0.6 mole) of 4-phthalimido butan-2-one (7a) in 1000 ml of absolute methanol is added 96 g (0.6 mole) of bromine and the reaction mixture is stirred for 24 hours at room temperature. The precipitate, N-(4-bromo-3.3-dimethoxybutyl) phthalimide (8a) is filtered off, suspended in methanol and 30 ml of 10N sulfuric acid is added, after which the reaction mixture is heated until a clear solution is obtained. After cooling down the precipitate is collected and recrystallized from hot methanol. Yield 60%. Melting point: 120-122 C. (lit: R. G. Jones et al., J. Am. Chem. Soc., 72, 4526-4529 (1950), 119-120 C.). 1 H-NMR (CDCl3): 3.13 ppm., triplet, 2H (J=7.2 Hz); 3.92 ppm.,. singlet, 2H; 4.04 ppm., triplet (J=7.2 Hz), 2H; 7.60-7.96 ppm., multiplet, 4H.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Oxobutyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Reference:
Patent; Cedona Pharmaceuticals B.V.; US5190589; (1993); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem