In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Potassium 1,3-dioxoisoindolin-2-ide
A solution of 2 (1.0 g, 4.4 mmol), potassium phthalimide (0.4 g, 2.2 mmol) in DMF (10 mL) was stirred at 90 C for 10 h. The mixture was poured into H2O (30 mL) and the suspension was extracted with EtOAc (2 × 30 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. Purification of the residue by flash chromatography (hexane:EtOAc, 20:1) gave 3 (0.41 g, 63%) as a white solid: mp 75-76.5 C; 1H NMR (300 MHz, CDCl3) delta 1.11 (s, 6H), 3.38 (s, 2H), 3.70 (s, 2H), 7.72-7.88 (m, 4H); 13C NMR (75 MHz, CDCl3) delta 24.6, 37.6, 44.5, 46.2, 123.3, 131.9, 134.1, 168.7; MS (ESI) m/z 318.0 [M+Na]+.
The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wu, Yong; Shi, Chen; Sun, Xiaowei; Wu, Xiaoming; Sun, Hongbin; Bioorganic and Medicinal Chemistry; vol. 19; 14; (2011); p. 4238 – 4249;,
Indoline – Wikipedia,
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