In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7477-63-6 as follows. Product Details of 7477-63-6
General procedure: To a stirred mixture of isatins (1mmol) and malononitrile/ethyl cyanoacetate (1mmol) in methanol (3ml), was added piperidine (10molpercent) and the reaction mixture was stirred at room temperature for 10min. Then 5,7-dihydroxy-4-methyl-2H-chromen-2-one (1mmol) was added to it. The resulting mixture was stirred at reflux until the reaction was completed as indicated by TLC. The resulting precipitate was treated with dilute HCl and washed with water to afford the pure product for analysis.
According to the analysis of related databases, 7477-63-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pal, Suman; Khan, Md. Nasim; Karamthulla, Shaik; Choudhury, Lokman H.; Tetrahedron Letters; vol. 56; 2; (2015); p. 359 – 364;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem