Reference of 1074-82-4,Some common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, molecular formula is C8H4KNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 3: Preparation of 2-5 (S){2-oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl)-oxazolidin- 5-ylmethyI}-isoindole-l,3-dione (III)60 gms of 4-[4-(5-chloromethyl-2-oxo-oxazolidin-3-yl)-phen l]-mophiholin-3-one , potassium phthalimide (40 g) and Nu,Nu-dimethyl formamide (400 ml) were charged into a clean and dry 4 neck R.B. flask. The resultant reaction mixture was heated to reflux for about 5 hours. After completion of the reaction, the reaction mixture was cooled to about 30C, poured into 2 L of water and the solid separated was filtered to give 50 gms of the title compound
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Potassium 1,3-dioxoisoindolin-2-ide, its application will become more common.
Reference:
Patent; SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; ANNA REDDY, ambati; VENKAT REDDY, buthukuri; WO2012/32533; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem