Synthetic Route of 102359-00-2, The chemical industry reduces the impact on the environment during synthesis 102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.
Example 1 :(3Z)-3-[(4-{[2-(diethylamino)ethyl]carbamoyl}-3,5-dimethyl-1H-pyrrol- 2-yl)methylene]-2-oxoindoline-5-carboxylic acid (1)A mixture of 2-oxoindoline-5-carboxylic acid (0.708 g, 4 mmol), 3,5-dimethyl-4- (piperidin-1 -ylcarbonyl)-1 /-/-pyrrole-2-carbaldehyde (1 .030 g, 4.4 mmol) and piperidine (0.2 ml_) in EtOH (75 ml_) was refluxed for 8 h. The mixture was cooled down to room temperature to provide a precipitate which was filtered and washed with EtOH to provide the target compound 1 (0.980 g, 62.25%).NMR (300 MHz, DMSO-c/6) delta ppm: 13.52 (s,1 H), 12.5 (bs,1 H), 1 1 .19 (s,1 H), 8.37 (s,1 H), 7.78 (s,1 H), 7.77 (d,1 H), 6.96 (d,1 H), 3.43 (m,4H), 2.29 (s,6H), 1 .60 (bs,2H), 1 .47 (bs,4H); tR: 3.18 min, MS (ESI): m/z (M+H)+ 394; (M+HV392.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Oxoindoline-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; FALCENBERG, Mathias; OeRFI, Zoltan; KERI, Gyoergy; OeRFI, Laszlo; HORVATH, Zoltan; SZOKOL, Balint; DOBOS, Judit; NEMES, Zoltan; WO2015/22437; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem