In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(2-Oxopropyl)isoindoline-1,3-dione
Example 491; N-[7-(3-Fluoro-benzenesulfonyl)-1-methyl-1 ,2,3,4-tetrahydro-benzofuro[2,3-c]pyridin-1-ylmeth isobutyramideStep 1 :2-(7-lodo-1-methyl-1 ,2,3,4-tetrahydro-benzofuro[2,3-c]pyridin-1-ylmethyl)- isoindole-1 ,3-dione To a mixture of 2-(6-iodo-benzofuran-3-yl)-ethylamine (2.00 g, 6.97 mmol) and 2-(2-oxo-propyl)- isoindole-1 ,3-dione (4.25 g, 20.9 mmol) was added trifluoroacetic acid (8.00 mL, 104 mmol) and then heated at 80 C . After 16 h, additional ketone (3 eq) was added and heating continued. After a total of 3 days, the reaction mixture was basified (DCM-aq. NaHC03) and the resulting precipitate was filtered, rinsed with DCM and dried to give an off-white solid, mp 302-304 C dec; MS m/z 473 [M + H]+.
The synthetic route of 3416-57-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CEPHALON, INC.; BACON, Edward R.; BAILEY, Thomas R.; DUNN, Derek D.; HOSTETLER, Greg A.; MCHUGH, Robert J.; MORTON, George C.; ROSSE, Gerard C.; SALVINO, Joseph M.; SUNDAR, Babu G.; TRIPATHY, Rabindranath; WO2011/87712; (2011); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem