Electric Literature of 172078-33-0, These common heterocyclic compound, 172078-33-0, name is Indolin-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1E (100 mg, 423 mmol), compound 24A (63 mg, 465 mmol) and cesium carbonate (303 mg, 930mmol) were added to NMP (1 mL). The reaction solution was heated to 120 C and stirred for 2 hours, and then thereaction was quenched with water, and extracted with ethyl acetate (3 x 10 ml). The organic layer was washed withsaturated NaCl solution, dried over anhydrous sodium sulfate, filtered and evaporated to dryness. The residue waschromatographed on a silica gel plate (dichloromethane/methanol = 10: 1, Rf = 0.2) and purified to give compound 24B(yellow solid, 80 mg, 57%).LCMS (ESI) m/z: 336.1(M+1)+
Statistics shows that Indolin-5-ol is playing an increasingly important role. we look forward to future research findings about 172078-33-0.
Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; LONG, Chaofeng; CHEN, Zhengxia; CHEN, Xiaoxin; ZHANG, Yang; LIU, Zhuowei; LI, Peng; CHEN, Shuhui; LIANG, Guibai; XIE, Cheng; LI, Zhengwei; FU, Zhifei; HU, Guoping; LI, Jian; (276 pag.)EP3293177; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem