Month: November 2021

Authors Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL in WILEY-V C H VERLAG GMBH published article about SECONDARY AMIDES; N-ALKYLATION; CHEMOSELECTIVE REDUCTION; TERTIARY AMIDES; ACID; DERIVATIVES; CHEMISTRY; NITRILES; ESTERS; CARBON in [Pan, Yixiao; Luo, Zhenli; Xu, Xin; Zhao, Haoqiang; Han, Jiahong; Xu, Lijin] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China; [Fan, Qinghua] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2019, Cited 59. Formula: C8H7NO. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)(2)(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway.

About Indolin-2-one, If you have any questions, you can contact Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL or concate me.. Formula: C8H7NO

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Recently I am researching about AGOUTI-RELATED PROTEIN; STRUCTURAL BASIS; CYCLIC-PEPTIDES; DISCOVERY; DESIGN; POTENT; TARGETS; SPSB2; RECOGNITION; CYCLIZATION, Saw an article supported by the . Name: Indolin-2-one. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gueret, SM; Thavam, S; Carbajo, RJ; Potowski, M; Larsson, N; Dahl, G; Dellsen, A; Grossmann, TN; Plowright, AT; Valeur, E; Lemurell, M; Waldmann, H. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

Hot loop protein segments have variable structure and conformation and contribute crucially to protein-protein interactions. We describe a new hot loop mimicking modality, termed PepNats, in which natural product (NP)-inspired structures are incorporated as conformation-determining and-restricting structural elements into macrocyclic hot loop-derived peptides. Macrocyclic PepNats representing hot loops of inducible nitric oxide synthase (iNOS) and human agouti-related protein (AGRP) were synthesized on solid support employing macro-cyclization by imine formation and subsequent stereoselective 1,3-dipolar cycloaddition as key steps. PepNats derived from the iNOS DINNN hot loop and the AGRP RFF hot spot sequence yielded novel and potent ligands of the SPRY domain-containing SOCS box protein 2 (SPSB2) that binds to iNOS, and selective ligands for AGRP-binding melanocortin (MC) receptors. NP-inspired fragment absolute configuration determines the conformation of the peptide part responsible for binding. These results demonstrate that combination of NP-inspired scaffolds with peptidic epitopes enables identification of novel hot loop mimics with conformationally constrained and biologically relevant structure.

Name: Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Gueret, SM; Thavam, S; Carbajo, RJ; Potowski, M; Larsson, N; Dahl, G; Dellsen, A; Grossmann, TN; Plowright, AT; Valeur, E; Lemurell, M; Waldmann, H or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article B(C6F5)(3)-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles WOS:000543700400038 published article about H BOND ACTIVATION; CATALYZED METHYLATION; BORYLATION; REACTIVITY; COMPLEXES; METHANOL; FUNCTIONALIZATION; GENERATION; PYRROLES; AGONIST in [Basak, Shyam; Melen, Rebecca L.; Morrill, Louis C.] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Cardiff CF10 3AT, Wales; [Alvarez-Montoya, Ana; Winfrey, Laura; Pulis, Alexander P.] Univ Leicester, Sch Chem, Leicester LE1 7RH, Leics, England in 2020, Cited 60. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3. Safety of Indolin-2-one

The direct C3 alkylation of indoles and oxindoles is a challenging transformation, and only a few direct methods exist. Utilizing the underexplored ability of triaryl boranes to mediate the heterolytic cleavage of alpha-nitrogen C-H bonds in amines, we have developed a catalytic approach for the direct C3 alkylation of a wide range of indoles and oxindoles using amine-based alkylating agents. We also employed this borane-catalyzed strategy in an alkylation-ring opening cascade.

Safety of Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Basak, S; Alvarez-Montoya, A; Winfrey, L; Melen, RL; Morrill, LC; Pulis, AP or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Product Details of 59-48-3. In 2020.0 ORG LETT published article about ASYMMETRIC HECK; MATSUDA ARYLATIONS; ACYCLIC ALKENES; LIGANDS; OLEFINS; COMPLEXES in [Chen, Guihua; Cao, Jian; Wang, Qian; Zhu, Jieping] Ecole Polytech Fed Lausanne, Lab Synth & Nat Prod, Inst Chem Sci & Engn, SB,ISIC,LSPN, BCH 5304, CH-1015 Lausanne, Switzerland; [Chen, Guihua] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China; [Cao, Jian] Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Peoples R China in 2020.0, Cited 46.0. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3.

In the presence of a catalytic amount of Pd(TFA)(2) and a chiral Pyox ligand under oxygen atmosphere, oxidative Heck reaction between arylboronic acids and 4-substituted or 4,4-disubstituted cyclopent-1-enes afforded the chiral arylated products with concurrent creation of two stereocenters in good yields with excellent diastereo- and enantioselectivities.

About Indolin-2-one, If you have any questions, you can contact Chen, GH; Cao, J; Wang, Q; Zhu, JP or concate me.. Product Details of 59-48-3

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Authors Lee, J; Vinh, NB; Drinkwater, N; Yang, W; Sivaraman, KK; Schembri, LS; Gazdik, M; Grin, PM; Butler, GS; Overall, CM; Charman, SA; McGowan, S; Scammells, PJ in AMER CHEMICAL SOC published article about PLASMODIUM-FALCIPARUM M1; ACUTE NONLYMPHOCYTIC LEUKEMIA; MOLECULAR-DYNAMICS; CLINICAL-SIGNIFICANCE; EFFICIENT GENERATION; STRUCTURAL BASIS; AM1-BCC MODEL; CD13; BESTATIN; CANCER in [Lee, Jisook; Vinh, Natalie B.; Schembri, Luke S.; Gazdik, Michelle; Scammells, Peter J.] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville Campus, Parkville, Vic 3052, Australia; [Charman, Susan A.] Monash Univ, Monash Inst Pharmaceut Sci, Ctr Drug Candidate Optimisat, Parkville Campus, Parkville, Vic 3052, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Infect & Immun Program, Biomed Discovery Inst, Clayton Campus, Clayton, Vic 3800, Australia; [Drinkwater, Nyssa; Yang, Wei; Sivaraman, Komagal Kannan; McGowan, Sheena] Monash Univ, Dept Microbiol, Clayton Campus, Clayton, Vic 3800, Australia; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada; [Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Dept Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada; [Grin, Peter M.; Butler, Georgina S.; Overall, Christopher M.] Univ British Columbia, Life Sci Inst, Ctr Blood Res, Vancouver, BC V6T 1Z3, Canada in 2019, Cited 80. COA of Formula: C8H7NO. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inhibitors of the APN homologue from the malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1). Herein, we describe the rationale that underpins the repurposing of PfA-MI inhibitors as novel APN inhibitors. A series of novel hydroxamic acid analogues were developed using a structure-based design approach and evaluated their inhibition activities against APN. N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yOethyl)-4(methylsulfonamido)benzamide (6ad) proved to be an extremely potent inhibitor of APN activity in vitro, selective against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity against Ad293 cells and favorable physicochemical and metabolic stability properties. The combined results indicate that compound 6ad may be a useful lead for the development of anticancer agents.

COA of Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Lee, J; Vinh, NB; Drinkwater, N; Yang, W; Sivaraman, KK; Schembri, LS; Gazdik, M; Grin, PM; Butler, GS; Overall, CM; Charman, SA; McGowan, S; Scammells, PJ or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Recently I am researching about TOBACCO-MOSAIC-VIRUS; LULICONAZOLE; BIOACTIVITY; MECHANISMS; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21867002]. SDS of cas: 59-48-3. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

Thirty unreported indole derivatives containing dithioacetal moiety were synthesized and evaluated for antiplant viral activity. Bioassay results displayed that some of the target compounds showed better activities against tobacco mosaic virus (TMV) than the commercial Ribavirin in vivo. In particular, anti-TMV curative, protective and inactivating activity of 4p were 55.1, 57.2, and 80.3%, respectively, and EC50 value for inactivating activity was 88.5 mu g/mL. The observation of transmission electron microscope showed that 4p may have a certain destructive effect on TMV particles. To further study, microscale thermophoresis analysis result also demonstrated that 4p powerfully interacted with TMV coat protein in vitro. Hence, this study provides a strong evidence suporting that indole derivatives might be applied as new antiviral agents.

About Indolin-2-one, If you have any questions, you can contact Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA or concate me.. SDS of cas: 59-48-3

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

An article Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors WOS:000526405300016 published article about SPHINGOLIPID METABOLISM; CELLULAR-RESPONSES; GAUCHER-DISEASE; SPHINGOSINE-1-PHOSPHATE; POTENT; GLUCOSYLSPHINGOSINE; GLUCOSYLCERAMIDE; ACCUMULATION; PURIFICATION; DEFICIENCY in [Lansbury, Peter; Liu, Min; Skerlj, Renato] Lysosomal Therapeut Inc, Cambridge, MA 02139 USA; [Di Martino, Simona; Tardia, Piero; Cilibrasi, Vincenzo; Caputo, Samantha; Mazzonna, Marco; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Pizzirani, Daniela; Scarpelli, Rita] Fdn Ist Italiano Tecnol, Drug Discovery & Dev D3 Validat, I-16163 Genoa, Italy; [Russo, Debora; Penna, Ilaria] Fdn Ist Italiano Tecnol, D3 Pharma Chem, I-16163 Genoa, Italy; [Ottonello, Giuliana; Bertozzi, Sine Mandrup; Armirotti, Andrea] Fdn Ist Italiano Tecnol, Analyt Chem Lab, I-16163 Genoa, Italy; [Duc Nguyen; Bongarzone, Ernesto R.] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Myelin Regenerat Grp, Chicago, IL 60612 USA; [Sun, Ying] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Dept Pediat,Div Human Genet, Cincinnati, OH 45229 USA in 2020.0, Cited 58.0. Quality Control of Indolin-2-one. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine 22m, where we demonstrated target engagement in two animal models of neuropathic lysosomal storage diseases (LSDs), Gaucher’s and Krabbe’s diseases. After daily intraperitoneal administration at 90 mg kg(-1), 22m significantly reduced the brain levels of the toxic lipids glucosylsphingosine (GluSph) in 4L;C* mice and galactosylsphingosine (GalSph) in Twitcher mice. We believe that 22m is a lead molecule that can be further developed for the correction of severe neurological LSDs where GluSph or GalSph play a significant role in disease pathogenesis.

Quality Control of Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Di Martino, S; Tardia, P; Cilibrasi, V; Caputo, S; Mazzonna, M; Russo, D; Penna, I; Realini, N; Margaroli, N; Migliore, M; Pizzirani, D; Ottonello, G; Bertozzi, SM; Armirotti, A; Nguyen, D; Sun, Y; Bongarzone, ER; Lansbury, P; Liu, M; Skerlj, R; Scarpelli, R or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

I found the field of Chemistry very interesting. Saw the article One-Pot Regiodirected Annulations for the Rapid Synthesis of pi-Extended Oligomers published in 2020.0. Formula: C8H7NO, Reprint Addresses Pasini, D (corresponding author), Univ Pavia, Dept Chem, I-27100 Pavia, Italy.; Pasini, D (corresponding author), Univ Pavia, INSTM Res Unit, I-27100 Pavia, Italy.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

We demonstrate the broad applicability of the annulation protocol combining, in one pot, a direct arylation and cross aldol condensation for the straightforward synthesis at gram-scale of pi-extended thiophene-based scaffolds. The regiospecific direct arylation drives the subsequent cross-aldol condensation proceed under the same basic conditions, and the overall protocol has broad applicability in the synthesis of extended aromatics wherein the thiophene ring is annulated with furans, pyridines, indoles, benzothiophenes, and benzofurans. These scaffolds can be further elaborated into pi-extended, highly fluorescent oligomers with a central deficient benzothiadiazole unit with up to nine aromatic rings through coupling reactions.

Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Nitti, A; Osw, P; Calcagno, G; Botta, C; Etkind, SI; Bianchi, G; Po, R; Swager, TM; Pasini, D or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Formula: C8H7NO. Recently I am researching about ELECTROINITIATED POLYMERIZATION; CARBON-DIOXIDE; VISIBLE-LIGHT; ELECTROCHEMICAL DICARBOXYLATION; STYRENE; CO2; ALKENES; ELECTROCARBOXYLATION; CARBOXYLATION; KINETICS, Saw an article supported by the Loughborough University; CARA; EPSRC CO2Chem Grand Challenge NetworkUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Alkayal, A; Tabas, V; Montanaro, S; Wright, IA; Malkov, AV; Buckley, BR. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, beta-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from beta,beta-trisubstituted alkenes, in a highly regioselective manner.

Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Alkayal, A; Tabas, V; Montanaro, S; Wright, IA; Malkov, AV; Buckley, BR or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem

Authors Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about TOBACCO-MOSAIC-VIRUS; LULICONAZOLE; BIOACTIVITY; MECHANISMS; DESIGN in [Wei, Chunle; Zhao, Lei; Sun, Zhongrong; Hu, Deyu; Song, Baoan] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China in 2020.0, Cited 33.0. Application In Synthesis of Indolin-2-one. The Name is Indolin-2-one. Through research, I have a further understanding and discovery of 59-48-3

Thirty unreported indole derivatives containing dithioacetal moiety were synthesized and evaluated for antiplant viral activity. Bioassay results displayed that some of the target compounds showed better activities against tobacco mosaic virus (TMV) than the commercial Ribavirin in vivo. In particular, anti-TMV curative, protective and inactivating activity of 4p were 55.1, 57.2, and 80.3%, respectively, and EC50 value for inactivating activity was 88.5 mu g/mL. The observation of transmission electron microscope showed that 4p may have a certain destructive effect on TMV particles. To further study, microscale thermophoresis analysis result also demonstrated that 4p powerfully interacted with TMV coat protein in vitro. Hence, this study provides a strong evidence suporting that indole derivatives might be applied as new antiviral agents.

Application In Synthesis of Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA or concate me.

Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem