Synthetic Route of 169037-23-4,Some common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, molecular formula is C9H4F3NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-TRIFLUOROMETHOXY-1H-INDOLE-2, 3-dione (3.48g, 15.0 MMOL) was dissolved in 2N aqueous sodium hydroxide (90MI) and cooled to 17 C before adding 30% aqueous hydrogen peroxide solution (2. 75ml, 27 MMOL) dropwise over 20 minutes. The mixture was stirred at room temperature for 1 hour before adding concentrated hydrochloric acid (7ml). The resulting brown precipitate was filtered off and DRIED IN VACUO at 50 C for 66 hours to give the title compound (1.83g) as a brown solid. APCI MS M/Z 220 [M-H] + 1H NMR (400MHZ, DMSO): 8 6.80 (d, 1H) 7.24 (dd, 1H), 7.53 (d, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-(Trifluoromethoxy)indoline-2,3-dione, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem