Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Product Details of 3783-77-5
Using general procedure B, the piperidine (62.3 mg, 0.19 mmol) and 2-(3-oxo-butyl)- isoindole-l,3-dione (108 mg, 0.50 mmol) gave the desired tertiary amine as a white foam (47.5 mg, 0.090 mmol, 47%).; General procedure B: Reductive Animation with NaCNBH3[0096] To a stirred solution of the amine (1 equivalent) in MeOH (concentration -0.1M) at room temperature were added the carbonyl compound (1-3 equivalents), glacial AcOH (0-1 equivalents) and sodium cyanoborohydride (NaCNBH3) (~1.5-3 equivalents) and the resultant solution was heated to reflux, hi a standard workup, the reaction mixture was concentrated under reduced pressure and diluted with saturated aqueous NaHCO3. The aqueous was extracted with CH2Cl2 and the combined organic extracts were dried (Na2SO4 or mgSO4), filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography on silica gel or by recrystallization.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem