Some common heterocyclic compound, 3485-84-5, name is N-Vinylphthalimide, molecular formula is C10H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H7NO2
Using N-vinylphthalimide and diphenylphosphine oxide as raw materials, the reaction steps are as follows:(1) Add N-vinylphthalimide (0.069 g, 0.4 mmol) to the reaction flask, diphenylphosphine oxide (0.081 g, 0.4 mmol),tert-butyl nitrite (0.041 g, 0.4 mmol), silver nitrate (0.07g, 0.04 mmol), ethanol (2.5mL), 30C reaction;(2) TLC tracks the reaction until complete;(3) The crude product obtained after completion of the reaction was separated by column chromatography (ethyl acetate:petroleum ether=1:1) to give the target product (yield 71%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3485-84-5, its application will become more common.
Reference:
Patent; Jiangsu Qiangsheng Function Chemical Co., Ltd.; Zou Jianping; Ying Zhiyao; Zhang Peizhi; Tao Zekun; Li Jianan; (19 pag.)CN107573378; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem