3335-98-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3335-98-6 as follows.
PREPARATION M7 1-Phenyl-3-(hydroxymethylene)-2(1H,2H)-indolone Potassium t-butoxide (1.63 g, 14.5 mmoles) and 5 ml absolute ethanol were heated to 80. 1-Phenyl-2(1H,3H)-indolone (2.09 g, 10 mmoles) was added, followed by ethyl formate (1.09 ml, 13.5 mmoles). The mixture was heated 5 minutes, cooled to 25, and the nearly solid mass diluted with 50 ml H2 O and crushed ice, acidified to pH 3 with 3N HCl and title product recovered by filtration, 2.2 g, m.p. 192-195; m/e 237. cf J. Prakt. Chem. 135:345-360 (1932); J. Med. Chem. 8:637 (1965).
According to the analysis of related databases, 3335-98-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Pfizer Inc.; US4476307; (1984); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem