Electric Literature of 7477-63-6,Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Ethyl 7-(2,3-dioxoindolin-1-yl)heptanoate (2a). A solution of 1a (147mg, 1mmoL) in DMF (3mL) was cooled to ?5°C and K2CO3 (165.5mg, 1.2mmoL) was added. The mixture was stirred for 1h at ?5°C and 45 min at room temperature, then CH3OH (0.5mL) and KI (8.3mg, 0.05 mmoL) were added. After stirring for 15 min, a solution of ethyl 7-bromoheptanoate (237mg, 195muL, 1mmoL) in DMF (1mL) was added and the resulting reaction mixture was stirred at 60°C for 24 h. Upon completion, the reaction mixture was cooled, acidified with 10percent HCl and extracted with DCM (50mL×2). The extracts were pooled and DCM was evaporated under reduced pressure. Compound 2a was obtained as brown?yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Chloroisatin, its application will become more common.