Reference of 3891-07-4, The chemical industry reduces the impact on the environment during synthesis 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.
Team, in a 50 mL round bottom flask,The thiacalix [4] arene (721 mg, 1. OO mmol) was added,N-Light ethyl phthalimide(1.75 g, 8.57 mmol),Triphenylphosphine (800 mg, 3.05 mmol),Dry tetrahydrofuran 20 mL,Ice bath,Then diethylazodicarboxylate (531 mg, 3.05 mmol) was slowly added dropwise,After the addition, the reaction was stirred at room temperature for 48h,Hot methanol 20mL by adding, cooling,Precipitation of a large number of white solid crude products,The crude product was purified by column chromatography (eluent: ethyl acetate / n-hexane, nu / nu = 1/4) to give a white product, 748 mg, in 70% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Hydroxyethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guizhou university; ZENG, XI; SUN, QIANG; ZHAO, YUANHUI; MOU, LAN; (27 pag.)CN104177351; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem