Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid
Into a 1000-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 3-(l,3-dioxo-2,3-dihydro-lH-isoindol-2- yl)propanoic acid (40 g, 182.49 mmol, 1.00 equiv) in water (250 mL). This was followed by the addition of aniline (17 g, 182.55 mmol, 1.00 equiv). To this was added sodium carbonate (9.6 g, 90.57 mmol, 0.50 equiv). The resulting solution was stirred for 3 h at 25 C. The pH value of the solution was adjusted to 5-6 with hydrochloric acid (1 mol/L). The solids were collected by filtration. The filter cake was washed with 1×200 mL of water. This resulted in 40 g (74%) of 3-(l,3-dioxo- 2,3-dihydro-lH-isoindol-2-yl)-N-phenylpropanamide as a white solid. MS (ESI) m/z 295 ([M + H]+)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3339-73-9.
Reference:
Patent; REXAHN PHARMACEUTICALS, INC.; LEE, Young Bok; KIM, Jae Min; KIM, Deog Joong; AHN, Chang-Ho; WO2014/143960; (2014); A1;,
Indoline – Wikipedia,
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