Introduction of a new synthetic route about 1029691-06-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-(3-Oxocyclopentyl)isoindoline-1,3-dione

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-(3-Oxocyclopentyl)isoindoline-1,3-dione

To a stirred solution of 200 mg (0.87 mmol) of 2-(3-oxocyclopentyl)isoindoline-1,3-dione (CAS 1029691-06-2) in 5 mL of DCM at 0C were added 10mg (0.26 mmol) of NaBH4 and then lmL of MeOH. Themixture was stirred at this temperature for 0.5 h. 20 mL of H20 was added and the mixture was extractedwith DCM. The combined organic layers were dried over Na2SO4 and then concentrated under vacuum. The residue was purified by silica gel column chromatography (PE/ EA = 2/1) to give 96 mg of the product as a white solid.MS (ESI+): 232.0 [M+H].?H NMR (400 MHz, DMSO-d6) ppm: 7.76-7.83 (m, 5H), 4.80 (d, J = 5.2 Hz, 1H), 4.43 (m, 1H), 4.06 (m, 1H), 1.64-2.15 (m, 6H).

The synthetic route of 1029691-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASILEA PHARMACEUTICA AG; POHLMANN, Jens; STIEGER, Martin; REINELT, Stefan; LANE, Heidi; (286 pag.)WO2016/128465; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem