Electric Literature of 1074-82-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-82-4 as follows.
Synthesis of Compound 32.1 [0281] To a solution of potassium l,3-dioxoisoindolin-2-ide (18.5 g, 0.1 mol, 1.0 eq) in acetone (200 mL) was added 1,6-dibromohexane (43.5 g, 0.18 mol, 1.8 eq). The mixture was stirred at 65 C for 12 h. After cooling down, the mixture was filtered to remove the precipitated salt. The filtrate was concentrated and the residue purified by a short silica gel column (PE : EA = 10 : 1) to remove the excess 1,6-dibromohexane. 16.1 g of 32.1was obtained as a yellow oil (yield: 52%). 1H NMR (400MHz, DMSO- 6)D delta: 7.88-7.82 (m, 4H), 3.58-3.49 (m, 4H), 1.81-1.74 (m, 2H), 1.63-1.55 (m, 2H), 1.44-1.27 (m, 4H); ESI-MS (M+H) +: 312.1.
According to the analysis of related databases, 1074-82-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOGEN IDEC MA INC.; JENKINS, Tracy; VESSELS, Jeffery; WO2014/143672; (2014); A1;,
Indoline – Wikipedia,
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