Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 150560-58-0, name is 5-Isopropylindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Formula: C11H11NO2

General procedure: A mixture of PPh3 (1.1 eq), isatin or 5-nitro-isatin (1.0 eq), andsubstituted 2-bromoacetate (1.1 eq) was heated at 80 C, then morpholine (1.1 eq) was added. After the reaction completion and cooling to the room temperature, the mixture was diluted with water, extracted with CH2Cl2, and the organic phase was dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by chromatography using Petroleum ether/Ethyl acetate to give the target compounds.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 150560-58-0.

Reference:
Article; Song, Zhuang; Chen, Cai-Ping; Liu, Jun; Wen, Xiaoan; Sun, Hongbin; Yuan, Haoliang; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 809 – 819;,
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Adding a certain compound to certain chemical reactions, such as: 675109-45-2, name is 6-Amino-2,3-dihydro-1H-isoindol-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 675109-45-2, Recommanded Product: 6-Amino-2,3-dihydro-1H-isoindol-1-one

General procedure: Isoindolin-1-one (200 mg, 1.50mmol) was dissolved in super-dry DMSO (4 mL), and Cs2CO3 (1215 mg, 3.75 mmol), CuI (58 mg, 0.30mmol) and N1,N2-dimethylethane-1,2-diamine (27 mg, 33 muL, 0.30 mmol) were added to the solution.The resulting mixture was stirred at room temperature for 10 min, after which iodobenzene (2.25mmol) was added. Then the mixture was heated to 120 C. When TLC showed that isoindolin-1-onehad been fully converted, the reaction was stopped. The mixture was extracted with ethyl acetate (20mL) and H2O (10 mL). The water phase was re-extracted with ethyl acetate (20 mL). The organic layerwas combined and washed with brine (10 mL). Then the solution was dried over anhydrous MgSO4,filtered and concentrated, and the crude residue was purified by flash chromatography over silica gelusing CH2Cl2/CH3OH as the gradient elution to afford the title compounds.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Amino-2,3-dihydro-1H-isoindol-1-one, and friends who are interested can also refer to it.

Reference:
Article; Wang, Yixuan; Wang, Huiqiang; Jiang, Xinbei; Jiang, Zhi; Guo, Tingting; Ji, Xingyue; Li, Yanping; Li, Yuhuan; Li, Zhuorong; Molecules; vol. 24; 5; (2019);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59-48-3, name is Indolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., category: indolines-derivatives

5-Nitro-2-Oxindole 2-Oxindole (6.5 g) was dissolved in 25 mL concentrated sulfuric acid and the mixture maintained at -10 to -15 C. while 2.1 mL of fuming nitric acid was added dropwise. After the addition of the nitric acid the reaction mixture was stirred at 0 C. for 0.5 hr and poured into ice-water. The precipitate was collected by filtration, washed with water and crystallized from 50% acetic acid. The crystalline product was then filtered, washed with water and dried under vacuum to give 6.3 g (70%) of 5-nitro-2-oxindole.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 59-48-3.

Reference:
Patent; Sugen. Inc.; US2003/100555; (2003); A1;,
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Indoline | C8H9N – PubChem

Adding a certain compound to certain chemical reactions, such as: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-72-2, SDS of cas: 2058-72-2

A mixture of 5-methoxy-N-methylisatin 1b (0.17g, 0.90mmol) and tryptamine (2) (0.16g, 1.00mmol) in EtOH (5mL) in the presence of glacial acetic acid (0.2mL) and 4A molecular seive were stirred at room temperature for 24h. The reaction mixture was filtered and washed with EtOH. The filtrate was concentrated and the residue was purified by column chromatography on silica gel using hexane:EtOAc (2:1) as an eluent to give spiro 3b (0.26g, 87%) as beige solid; m.p. 243-245C (lit. [25] 255-256C); 1H NMR (300MHz, CDCl3) delta 2.98 (t, J=5.7Hz, 2H, CH2), 3.25 (s, 3H, CH3), 3.34 (dt, J=5.4, 13.2Hz, 1H, CH2), 3.72 (s, 3H, OCH3), 3.88 (dt, J=6.3, 13.2Hz, 1H, CH2), 6.81-6.91 (m, 3H, ArH), 7.08-7.19 (m, 3H, ArH), 7.29 (br s, 1H, NH), 7.57 (d, J=5.9Hz, 1H, ArH); 13C NMR (75MHz, CDCl3) delta 22.0, 26.6, 40.0, 55.9, 62.0, 109.4, 111.2, 111.6, 111.9, 114.7, 118.4, 119.4, 122.3, 127.0, 129.9, 132.7, 136.4, 136.9, 156.6, 176.7.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-1-methylindoline-2,3-dione, and friends who are interested can also refer to it.

Reference:
Article; Rattanopas, Sopita; Piyanuch, Pornthip; Wisansin, Kawintip; Charoenpanich, Adisri; Sirirak, Jitnapa; Phutdhawong, Waya; Wanichacheva, Nantanit; Journal of Photochemistry and Photobiology A: Chemistry; vol. 377; (2019); p. 138 – 148;,
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20780-72-7, name is 4-Bromoisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Bromoisatin

General procedure: To a stirred solution of N-Boc-3-pyrrolin-2-one (1, 36.6 mg, 0.20 mmol), K2CO3 (2.8 mg, 0.020 mmol,20 mol percent) in water (2.0 mL), was added isatin (2a, 14.7 mg, 0.10 mmol) at room temperature. Thereaction mixture was stirred for 4 h (monitored by TLC). The reaction mixture was then extracted withethyl acetate (3 x 5 mL). The combined organic layers were dried with Na2SO4 and the solvent wasthen evaporated under reduced pressure. The crude reaction mixture thus obtained was purified bysilica gel using flash column chromatography (40:60 hexane/AcOEt) to give the MBH product 4a(31.0 mg, 94percent yield)

The synthetic route of 20780-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramireddy, Naresh; Zhao, John C.-G.; Tetrahedron Letters; vol. 55; 3; (2014); p. 706 – 709;,
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Related Products of 17702-83-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17702-83-9 name is 2-(8-Bromooctyl)isoindoline-1,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(8-bromodecyl)isoindoline-1 ,3-dione (0.91 g, 2.70 mmol) and tris(4- methoxyphenyl)phosphine (1 g, 2.84 mmol) in MeCN (10 mL) was heated at 70 °C overnight. On cooling the solvent was removed in vacuo and the resulting residue purified by column chromatography eluting with 10percent MeOH in DCM to give [8-(1 ,3-dioxo-2,3-dihydro-1 H- isoindol-2-yl)octyl]tris(4-methoxyphenyl)phosphonium bromide (1.56 g, 82percent) as a white foam. [00283] 1 H NMR (Method A) (DMSO-d6): delta (delta) ppm 7.88-7.81 (4H, m), 7.65 (6H, m), 7.28 (6H, m), 3.88 (9H, s), 3.54 (2H, t), 3.31 (2H, m), 1.61 -1 .36 (6H, m), 1.23 (6H, m); 31 P NMR (162 MHz, DMSO-de): delta (delta) ppm +21 .7 ppm; LC-MS (Method G) 610 [M]+; RT 2.13 min

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(8-Bromooctyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.

Reference:
Patent; NOVINTUM BIOTECHNOLOGY GMBH; SPAREY, Tim; RATCLIFFE, Andrew; STEVENSON, Brett; LAGASSE, Franz; COCHRANE, Edward; FROIDBISE, Alexandre; LASSALLE, Gilbert; (120 pag.)WO2018/193126; (2018); A1;,
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Reference of 1127-59-9, These common heterocyclic compound, 1127-59-9, name is 7-Methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 0.31 g (1.1 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl acetate 14 and 0.03 mL of triethyl-amine were added to a continuously stirred solution of the isatin derivative 1?13 (1 mmol) in DMF. The reaction was performed at 70°, completion of the reaction of the reactants was determined by TLC. After cooling to ambient, the reaction mixture was poured into a brine. The obtained precipitate was filtered off, washed with water, and dried in vacuum (12 mmHg).

The synthetic route of 1127-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bogdanov; Zaripova; Voloshina; Strobykina; Kulik; Bukharov; Mironov; Russian Journal of General Chemistry; vol. 88; 1; (2018); p. 57 – 67; Zh. Obshch. Khim.; vol. 88; 1; (2018); p. 61 – 71,11;,
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Indoline | C8H9N – PubChem

Electric Literature of 7699-18-5, The chemical industry reduces the impact on the environment during synthesis 7699-18-5, name is 5-Methoxyindolin-2-one, I believe this compound will play a more active role in future production and life.

General procedure: The appropriate indolin-2-one (10 mmol) was dissolved in methanol (100 mL) and treated with the equivalent of the appropriate imidazo[2,1-b]thiazole-5-carbaldehyde 2 and piperidine (1 mL toobtain compounds 6, 8, 10) or 37% hydrochloric acid (1 mL to obtain compounds 7, 9). The reaction mixture was refluxed for 8-13 h (according to a TLC test), and the precipitate formed on cooling was collected by filtration.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methoxyindolin-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Conti, Ilaria; Morigi, Rita; Locatelli, Alessandra; Rambaldi, Mirella; Bua, Gloria; Gallinella, Giorgio; Leoni, Alberto; Molecules; vol. 24; 6; (2019);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6326-79-0, name is 6-Bromoisatin, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H4BrNO2

To a solution of compound 10 (10 g, 44.24 mmol) inEtOH (130 mL) was added a solution of hydroxylamine hydrochloride(4.61 g, 66.34 mmol) in H2O (20 mL) and the mixture was stirred at 80 C for 12 h. The mixture was concentrated under reduced pressure and the solid formed was filtered, washed with cold water, and dried under high vacuum to afford 10.24 g (96%) of compound 11 as a blood-red solid. IR (KBr) max. cm-1: 3336, 3330 (NH2), 3310 (OH),3038 (Ar-H), 2920 (Alph-H), 1690 (C=O), 1612, 1515, 1414(C=C), 1260 (C-N). 1H NMR (500 MHz, DMSO-d6) =7.02 (s, 1H, H-7); 7.20 (d, 1H, J = 8.2 Hz, H-5); 7.84 (d, 1H,J = 8.1 Hz, H-4); 10.83 (s, 1H, NH); 13.49 (s, 1H, OH); 13CNMR (125.7 MHz, DMSO-d6) = 113.12 (aromatic-C),115.50 (aromatic-C), 124.84 (aromatic-C), 128.46 (aromatic-C), 143.48 (aromatic-C), 144.02 (aromatic-C), 164.29,167.12 (C=O). Calculated (%) for C8H5BrN2O2 (239.95); C:39.86, H: 2.09, N: 11.62, found (%); C: 39.80, H: 2.14, N:11.58.

According to the analysis of related databases, 6326-79-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ullah, Nisar; Medicinal Chemistry; vol. 10; 5; (2014); p. 484 – 496;,
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Synthetic Route of 99365-40-9,Some common heterocyclic compound, 99365-40-9, name is 6-Bromoindolin-2-one, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6-(Furan-2-yl)-oxindole 6-Bromo-oxindole (0.40 g, 1.88 mmol), 2-tributyltinfuran (0.71 ML, 2.26 mmol), and tetraethylammonium chloride hydrate (0.31 g, 1.88 mmol) were combined and dissolved in acetonitrile (15 ML).. The palladium catalyst, bistriphenylphosphinedichloropalladium (II) (0.66 g, 0.09 mmol) was added and the reaction was warmed to 85 C. under nitrogen for 20 h.. The reaction was cooled to room temperature and diluted with water (15 ML) before passing the mixture through celite.. The pad of celite was washed with EtOAc and the filtrates were combined and separated.. The aqueous layer was washed with EtOAc (2*20 ML each).. The combined organic phases were washed with brine and dried over sodium sulfate.. The volatiles ere removed in vacuo.. The resulting residue was triturated with diethyl ether and the solid was collected by filtration (0.13 g, 34%). 1H NMR 300 MHz (DMSO-d6) delta 10.5 (s, 1H); 7.75 (s, 1H); 7.30 (m, 2H); 7.11 (s, 1H); 6.91 (m, 1H); 6.60 (m, 1H); 3.52 (s, 2H).

The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Glaxo Wellcome Inc.; US6350747; (2002); B1;,
Indoline – Wikipedia,
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